Macrophages as Effectors of Acute and Chronic Allograft Injury.
Macrophages as Effectors of Acute and Chronic Allograft Injury.
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DOI：
10.1007/s40472-016-0130-9
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发表时间：
2016-12
影响因子：
2.1
通讯作者：
Li XC
中科院分区：
文献类型：
--
作者：
Liu Y;Kloc M;Li XC
器官移植给终末期器官衰竭的病人第二次生命的机会。然而，免疫障碍被证明是非常具有挑战性的，移植物排斥反应仍然是长期移植生存的主要障碍。几十年来，适应性免疫一直是研究的焦点，主要基于T细胞对排异反应是必要和充分的信念。随着免疫抑制药物的发展和对适应性细胞的有效控制，先天免疫细胞成为引发移植物损伤的关键效应细胞，近年来受到广泛关注。在这篇综述中，我们讨论了目前对巨噬细胞的理解及其在移植排斥反应中的作用，它们的动力学，不同的表型，位置和功能。我们还讨论了正在开发的针对移植受者巨噬细胞的新治疗方法。
Organ transplants give a second chance of life to patients with end-stage organ failure. However, the immuno-logical barriers prove to be very challenging to overcome and graft rejection remains a major hurdle to long-term transplant survival. For decades, adaptive immunity has been the focus of studies, primarily based on the belief that T cells are necessary and sufficient for rejection. With better-developed immunosuppressive drugs and protocols that effectively control adaptive cells, innate immune cells have emerged as key effector cells in triggering graft injury and have therefore attracted much recent attention. In this review, we discuss current understanding of macrophages and their role in transplant rejection, their dynamics, distinct phenotypes, locations, and functions. We also discuss novel therapeutic approaches under development to target macrophages in transplant recipients.