HIPPOCAMPAL-LESIONS IMPAIR MEMORY OF SHORT-DELAY CONDITIONED EYE BLINK IN RABBITS
HIPPOCAMPAL-LESIONS IMPAIR MEMORY OF SHORT-DELAY CONDITIONED EYE BLINK IN RABBITS
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DOI：
10.1037/0735-7044.103.5.935
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发表时间：
1989-10-01
影响因子：
1.9
通讯作者：
DISTERHOFT, JF
中科院分区：
文献类型：
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作者：
AKASE, E;ALKON, DL;DISTERHOFT, JF
在条件反应（CR）巩固过程中，重新检查了海马在短延迟眨眼调节中的参与情况。兔子接受双侧海马切除术，去除覆盖的新皮质或假损伤，并通过音调/吹气配对进行训练，以早期习得（巩固）或良好训练（过度训练）；测试了保留率。观察到两种效果：1）海马损伤的兔子在巩固实验中表现出比对照组更少的保留。之前的研究可能没有发现这一点，因为最初的训练更加完整。过度训练的海马兔表现出更多的记忆力，这与这一建议一致。 2）海马切除的兔子在过度训练实验中表现出更大的CR幅度。讨论了海马在早期学习过程中的巩固过程中以及在充分学习关联后调节行为条件反应的幅度/时间过程的表达方面的互补作用。
Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairing to early acquisition (consolidation) or well trained (overtraining); retention was tested. Two effects were observed: 1) Rabbits with hippocampal lesions showed less retention in the consolidation experiment than controls. Previous studies may not have found this because initial training was more complete. Overtrained hippocampal rabbits showed more retention, which agrees with this suggestion. 2) Hippocampectomized rabbits showed larger CR amplitudes in the overtraining experiment. The complementary roles of hippocampus in the consolidation process during early learning and in modulating the expression of the amplitude/time course of behavioral conditioned responses after associations are well learned are discussed.