Thalamic shape and volume abnormalities in female patients with panic disorder
Thalamic shape and volume abnormalities in female patients with panic disorder
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DOI：
10.1371/journal.pone.0208152
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发表时间：
2018-12-19
期刊：
影响因子：
3.7
通讯作者：
Hirayasu, Yoshio
中科院分区：
文献类型：
--
作者：
Asami, Takeshi;Yoshida, Haruhisa;Hirayasu, Yoshio
丘脑在惊恐障碍（PD）患者的内脏感觉信息处理和杏仁核活动调节中起着重要作用。先前的功能性神经影像学研究已经检测到与健康对照受试者（HC）相比，PD患者丘脑的异常激活。然而，很少有研究调查PD患者丘脑的体积异常。此外，据我们所知，没有以前的研究已经调查了形状异常的丘脑PD患者。本研究招募了25例PD患者和25例HC受试者（均为女性）。进行逐体素体积比较分析和逐顶点形状分析，以评价与HC相比PD患者的结构异常。PD患者表现出显着的灰质体积减少，在丘脑双侧，相对于HC。形态分析发现PD患者丘脑前核、背内侧核、枕核等部分区域明显向内变形。PD患者在关键的丘脑区域表现出形状变形，这些区域被认为在调节情绪和认知功能中起作用。
The thalamus is believed to play crucial role in processing viscero-sensory information, and regulating the activity of amygdala in patients with panic disorder (PD). Previous functional neuroimaging studies have detected abnormal activation in the thalamus in patients with PD compared with healthy control subjects (HC). Very few studies, however, have investigated for volumetric abnormalities in the thalamus in patients with PD. Furthermore, to the best of our knowledge, no previous study has investigated for shape abnormalities in the thalamus in patients with PD. Twenty-five patients with PD and 25 HC participants (all female) were recruited for the study. A voxel-wise volume comparison analysis and a vertex-wise shape analysis were conducted to evaluate structural abnormalities in the PD patients compared to HC. The patients with PD demonstrated significant gray matter volume reductions in the thalamus bilaterally, relative to the HC. The shape analysis detected significant inward deformation in some thalamic regions in the PD patients, including the anterior nucleus, mediodorsal nucleus, and pulvinar nucleus. PD patients showed shape deformations in key thalamic regions that are believed to play a role in regulating emotional and cognitive functions.