Personal exposure to submicrometer particles and heart rate variability in human subjects.
Personal exposure to submicrometer particles and heart rate variability in human subjects.
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人类受试者的个人暴露于亚微米颗粒和心率变异性。
DOI：
10.1289/ehp.6897
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发表时间：
2004-07
影响因子：
10.4
通讯作者：
Lin, Lian-Yu
中科院分区：
文献类型：
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作者：
Chan, Chang-Chuan;Chuang, Kai-Jen;Shiao, Guang-Ming;Lin, Lian-Yu
我们对两组人类受试者（9名年轻人和10名肺功能受损的老年患者）进行了一项研究，以评估亚微米颗粒物空气污染是否与心率变异性（HRV）相关。我们在白天连续测量了这些受试者的心电图和个人暴露于尺寸范围为0.02-1 μm（NC 0.02 -1）的亚微米颗粒物的数量浓度。我们使用线性混合效应模型来估计NC 0.02 -1和log 10转换的HRV之间的关系，包括所有正常-正常间期的标准差（SDNN）、相邻NN间期之间差值平方和的平均值的平方根（r-MSSD）、低频低频（LF，0.04-0.15 Hz）和高频（HF，0.15-0.40 Hz），根据年龄、性别、体重指数、烟草暴露和温度进行调整。对于年轻样本组，NC0.02-1增加10，000个粒子/cm 3，1-4小时移动平均暴露与SDNN降低0.68-1.35%、r-MSSD降低1.85-2.58%、LF降低1.32-1.61%和HF降低1.57-2.60%相关。对于老年组，NC0.02-1增加10，000个微粒/cm 3，1-3小时移动平均暴露量与SDNN降低1.72-3.00%、r-MSSD降低2.72-4.65%、LF降低3.34-5.04%和HF降低3.61-5.61%相关。总之，暴露于NC0.02-1与人类受试者的时域和频域HRV指数降低相关。
We conducted a study on two panels of human subjects—9 young adults and 10 elderly patients with lung function impairments—to evaluate whether submicrometer particulate air pollution was associated with heart rate variability (HRV). We measured these subjects’ electrocardiography and personal exposure to number concentrations of submicrometer particles with a size range of 0.02–1 μm (NC0.02–1) continuously during daytime periods. We used linear mixed-effects models to estimate the relationship between NC0.02–1 and log10-transformed HRV, including standard deviation of all normal-to-normal intervals (SDNN), square root of the mean of the sum of the squares of differences between adjacent NN intervals (r-MSSD), low frequency (LF, 0.04–0.15 Hz), and high frequency (HF, 0.15–0.40 Hz), adjusted for age, sex, body mass index, tobacco exposure, and temperature. For the young panel, a 10,000-particle/cm3 increase in NC0.02–1 with 1–4 hr moving average exposure was associated with 0.68–1.35% decreases in SDNN, 1.85–2.58% decreases in r-MSSD, 1.32–1.61% decreases in LF, and 1.57–2.60% decreases in HF. For the elderly panel, a 10,000-particle/cm3 increase in NC0.02–1 with 1–3 hr moving average exposure was associated with 1.72–3.00% decreases in SDNN, 2.72–4.65% decreases in r-MSSD, 3.34–5.04% decreases in LF, and 3.61–5.61% decreases in HF. In conclusion, exposure to NC0.02–1 was associated with decreases in both time-domain and frequency-domain HRV indices in human subjects.