Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits.
Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits.
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周围神经再生策略：电刺激聚合物基于聚合物的神经生长导管。
DOI：
10.1615/critrevbiomedeng.2015014015
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发表时间：
2015
影响因子：
--
通讯作者：
Kumbar SG
中科院分区：
文献类型：
--
作者：
Anderson M;Shelke NB;Manoukian OS;Yu X;McCullough LD;Kumbar SG
大的周围神经损伤的治疗范围从使用自体神经移植物到合成神经生长导管。尽管生物移植物有许多优点，但在可用性和供体部位发病率方面显示出一些限制，并且由于束不匹配、瘢痕形成和纤维化，结果不理想。组织工程神经移植替代物利用聚合物导管结合化学和物理线索，细胞单独和/或组合。通过聚合物导管递送的化学和物理线索起着重要作用并驱动组织再生。电刺激（ES）已被应用于各种组织的修复和再生，如肌肉，肌腱，神经和关节组织在实验室和临床设置。ES后调节细胞活动如细胞粘附、增殖、细胞迁移、蛋白质产生和组织再生的潜在机制尚未完全了解。已经开发了可以沿着支架长度沿着携带电刺激的聚合物构建体，并表征其用于可能的神经再生应用。我们讨论了使用导电聚合物和相关的细胞相互作用，生物相容性，组织再生，和最近的神经再生的基础研究。总之，一个多功能的组合装置，包括生物材料，结构，功能，细胞和分子方面可能是最好的方法，有效的周围神经再生。
Treatment of large peripheral nerve damages ranges from the use of an autologous nerve graft to a synthetic nerve growth conduit. Biological grafts, in spite of many merits, show several limitations in terms of availability and donor site morbidity, and outcomes are suboptimal due to fascicle mismatch, scarring, and fibrosis. Tissue engineered nerve graft substitutes utilize polymeric conduits in conjunction with cues both chemical and physical, cells alone and or in combination. The chemical and physical cues delivered through polymeric conduits play an important role and drive tissue regeneration. Electrical stimulation (ES) has been applied toward the repair and regeneration of various tissues such as muscle, tendon, nerve, and articular tissue both in laboratory and clinical settings. The underlying mechanisms that regulate cellular activities such as cell adhesion, proliferation, cell migration, protein production, and tissue regeneration following ES is not fully understood. Polymeric constructs that can carry the electrical stimulation along the length of the scaffold have been developed and characterized for possible nerve regeneration applications. We discuss the use of electrically conductive polymers and associated cell interaction, biocompatibility, tissue regeneration, and recent basic research for nerve regeneration. In conclusion, a multifunctional combinatorial device comprised of biomaterial, structural, functional, cellular, and molecular aspects may be the best way forward for effective peripheral nerve regeneration.