Cohort Profile: The Christchurch IBS cOhort to investigate Mechanisms FOr gut Relief and improved Transit (COMFORT).
Cohort Profile: The Christchurch IBS cOhort to investigate Mechanisms FOr gut Relief and improved Transit (COMFORT).
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DOI：
10.1159/000508160
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发表时间：
2020-08-01
影响因子：
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通讯作者：
Gearry, Richard B
中科院分区：
文献类型：
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作者：
Heenan, Phoebe;Creemers, Rob H;Gearry, Richard B
背景和目标：这项横断面观察性病例对照研究于2016年7月启动，旨在增加对功能性胃肠道疾病（FGID）（包括肠易激综合征（IBS）、功能性腹泻（FD）和功能性便秘（FC））的基础疾病机制的了解。感兴趣的具体领域包括食物，微生物组，宿主和微生物遗传学，代谢组学和心理变量对不明原因的慢性胃肠道（GI）symptoms.METHODS的影响：本研究招募了连续的患者谁参加了两个内窥镜中心之一，在基督城，新西兰，结肠镜检查和一个小组的参与者从公众谁没有接受结肠镜检查。排除了患有除FGID以外的已知GI疾病的参与者。有症状的人被招募为病例，而没有症状的人被招募为对照。在准备结肠镜检查前几天，或未接受结肠镜检查的患者的适宜时间，除生物样本（呼吸、粪便、血液和尿液）外，还收集人口统计学、症状、心理、饮食和健康数据。结果：在2016年7月至2018年12月期间，共招募了349名参与者，其中315人完成了研究，220名参与者来自结肠镜检查亚组，95名来自非结肠镜检查亚组。这包括129例对照和186例病例（57例IBS-腹泻为主，30例IBS-便秘为主，41例IBS-混合型，42例FC和16例FD）。FGID病例的平均年龄为53.4岁，对照组为54.4岁。病例（149/186，80.1%）和对照（57/72，55.8%）主要是女性。整个队列的教育水平相似。吸烟和饮酒的比例也相似。按计划从Participants.CONCLUSIONS：COMFORT队列是一个独特的FGID病例和对照的临床队列，除了生物样本外，还具有广泛的人口统计学，饮食，临床，心理和健康数据。未来的研究将旨在使用系统生物学方法来确定饮食，宿主-微生物组相互作用和其他因素在FGID发病机制中的潜在作用。
BACKGROUND AND AIMS: This cross-sectional observational case-control study was initiated in July 2016 with the aim of increasing an understanding of the underlying disease mechanisms in functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional diarrhoea (FD), and functional constipation (FC). Specific areas of interest include the effect of food, microbiome, host and microbial genetics, metabolome, and psychological variables on unexplained chronic gastrointestinal (GI) symptoms.METHODS: This study recruited consecutive patients who were attending one of two endoscopy centres in Christchurch, New Zealand, for colonoscopy and a subgroup of participants from the general public who did not undergo colonoscopy. Participants with known GI disease other than an FGID were excluded. Those with symptoms were recruited as cases, whilst those without symptoms were recruited as controls. In the days prior to preparation for colonoscopy, or an agreeable time for those not undergoing colonoscopy, demographic, symptom, psychological, dietary, and health data were collected in addition to biological samples (breath, faeces, blood, and urine). Colonic biopsies were taken at the time of colonoscopy from participants in the colonoscopy subgroup.RESULTS: Between July 2016 and December 2018, 349 participants were recruited, 315 of whom completed the study, 220 participants were from the colonoscopy subgroup, and 95 from the non-colonoscopy subgroup. This included 129 controls and 186 cases (57 IBS-diarrhoea predominant, 30 IBS-constipation predominant, 41 IBS-mixed, 42 FC, and 16 FD). The mean age of FGID cases was 53.4 years and controls 54.4 years. Cases (149/186, 80.1%) and controls (57/72, 55.8%) were predominantly female. Education levels were similar across the cohort. Smoking and alcohol rates were also similar. Biological samples were collected as planned from participants.CONCLUSIONS: The COMFORT cohort is a unique clinical cohort of FGID cases and controls with a wide range of demographic, dietary, clinical, psychological, and health data in addition to biological samples. Future research will aim to use a systems biology approach to establish the potential role of diet, host-microbiome interactions, and other factors in the pathogenesis of FGIDs.