Cariogenicity of frequent aspartame and sorbitol rinsing in laboratory rats.
Cariogenicity of frequent aspartame and sorbitol rinsing in laboratory rats.
复制标题
实验室大鼠频繁冲洗阿斯巴甜和山梨醇的致龋性。
DOI：
10.1159/000261113
复制
发表时间：
1988
期刊：
影响因子：
4.2
通讯作者：
Rudney,J
中科院分区：
文献类型：
--
作者：
Lout,RK;Messer,LB;Soberay,A;Kajander,K;Rudney,J
在大鼠龋齿模型上，动物随机分为四组(16只/组)：0.05%阿斯巴甜、20%山梨醇、去离子蒸馏水和20%蔗糖；所有溶液均为pH 3.0。每天冲洗5次，连续21天，对下颌磨牙进行龋齿评分。表面光滑、近侧和根面龋病评分在两组间无显著差异。蔗糖组的中度牙本质沟龋患率显著高于阿斯巴甜、山梨醇和水组(p<；0.05)。用0.05%的阿斯巴甜(pH和浓度与碳酸饮料相似)或山梨醇冲洗并不能增强龋齿活性。
The cariogenicity of frequent rinsings with aspartame and sorbitol was studied in the rat caries model with animals randomly assigned to four oral rinse groups (16 rats/group): 0.05% aspartame, 20% sorbitol, deionized distilled water, and 20% sucrose; all solutions at pH 3.0. After rinsing five times daily for 21 days, mandibular molars were scored for caries. Smooth surface, proximal and morsal caries scores did not differ significantly between groups. Moderate dentinal sulcal caries for the sucrose group was significantly greater than in the aspartame, sorbitol, and water groups (p < 0.05). Rinsing with 0.05% aspartame (similar in pH and concentration to that found in carbonated beverages) or sorbitol did not potentiate caries activity.