Serum concentrations of estrogens, sex hormone binding globulin, and androgens and risk of breast hyperplasia in postmenopausal women.
Serum concentrations of estrogens, sex hormone binding globulin, and androgens and risk of breast hyperplasia in postmenopausal women.
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绝经后妇女的雌激素、性激素结合球蛋白和雄激素的血清浓度以及乳腺增生的风险。
DOI：
10.1158/1055-9965.epi-05-0017
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Sherman,MarkE
中科院分区：
文献类型：
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作者：
Schairer,Catherine;Hill,Deirdre;Sturgeon,SusanR;Fears,Thomas;Mies,Carolyn;Ziegler,ReginaG;Hoover,RobertN;Sherman,MarkE
目的：我们试图确定绝经后妇女的雌激素，雄激素和性激素结合球蛋白的血清浓度是否与乳腺增生的存在有关，乳腺增生是一个确定的乳腺癌危险因素.方法：研究参与者提供血清乳腺活检或乳房切除术前在三家医院在大急流城，密歇根州，1977年至1987年。共有179名乳腺增生受试者与152名与乳腺癌风险增加无关的非增生性乳腺变化受试者进行了比较。雌二醇的三个上四分位数与最低四分位数相比的比值比（OR）分别为2.2 [95%置信区间（95%CI）1.1-4.6]，2.5（95% CI，1.1-5.3）和4.1（95% CI，2.0-8.5; P趋势= 0.007）。生物可利用的雌二醇、雌酮和硫酸雌酮的相应OR值通常相似（生物可利用的雌二醇的Ptrend= 0.003，雌酮的Ptrend = 0.0004，硫酸雌酮的Ptrend = 0.0009）。相对于同时处于血清雌二醇、雌酮和硫酸雌酮最低三分位数的妇女，同时处于所有三种激素最高三分位数的妇女的OR为5.8（95%CI，2.2-15.2）。性激素结合球蛋白，睾酮，脱氢表雄酮，雄烯二酮和雄烯二醇的血清浓度与hyperplasia.Conclusions的风险无关：雌激素的血清浓度，但不是雄激素或性激素结合球蛋白，强烈和显着相关的绝经后妇女乳腺增生的风险，这表明雌激素是重要的早期病理过程对乳腺癌。
Objective: We sought to determine whether serum concentrations of estrogens, androgens, and sex hormone binding globulin in postmenopausal women were related to the presence of mammary hyperplasia, an established breast cancer risk factor.Methods: Study participants provided serum before breast biopsy or mastectomy in three hospitals in Grand Rapids, Michigan, between 1977 and 1987. A total of 179 subjects with breast hyperplasia were compared with 152 subjects with nonproliferative breast changes that are not associated with increased breast cancer risk.Results: The odds ratios (OR) associated with the three upper quartiles of estradiol in comparison with the lowest quartile were 2.2 [95% confidence interval (95% CI) 1.1-4.6], 2.5 (95% CI, 1.1-5.3), and 4.1 (95% CI, 2.0-8.5;Ptrend= 0.007). The corresponding ORs for bioavailable estradiol, estrone, and estrone sulfate were of generally similar magnitude (Ptrend= 0.003 for bioavailable estradiol, 0.0004 for estrone, and 0.0009 for estrone sulfate). Relative to women concurrently in the lowest tertile for serum estradiol, estrone, and estrone sulfate, women concurrently in the highest tertile for all three hormones had an OR of 5.8 (95% CI, 2.2-15.2). Serum concentrations of sex hormone binding globulin, testosterone, dehydroepiandrosterone, androstenedione, and androstenediol were not associated with risk of hyperplasia.Conclusions: Serum concentrations of estrogens, but not of androgens or sex hormone binding globulin, were strongly and significantly associated with risk of breast hyperplasia in postmenopausal women, suggesting that estrogens are important early in the pathologic process towards breast cancer.