Developmental aspects of language processing: fMRI of verbal fluency in children and adults
Developmental aspects of language processing: fMRI of verbal fluency in children and adults
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DOI：
10.1002/hbm.10091
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发表时间：
2003-03-01
影响因子：
4.8
通讯作者：
Grandin, CB
中科院分区：
文献类型：
--
作者：
Gaillard, WD;Sachs, BC;Grandin, CB
我们检查了成人和儿童在执行语义流畅性任务时 fiviRI 语言激活图的位置和范围的发育差异。我们使用块设计，使用隐性语义语言流畅性（与休息相比生成单词到类别），以 1.5 T 的回波平面成像 BOLD fMRI 对 29 名成人和 16 名儿童进行了研究。进行任务后测试以评估表现。使用来自 t 图 (t = 4) 和不对称指数 (AI) 的先验感兴趣区域方法对个体数据进行分析。使用 SPM 99（Wellcome，英国；固定效应，校正 P < 0.0001）对小组研究进行分析。我们发现成人和儿童在语义言语流畅性任务中激活的位置或偏侧性没有显着差异。成人在左侧额下回和左侧额中回激活的像素多于儿童，但各年龄段的 AI 相似（r(2) < 0.09）。激活的程度或横向性不受性能影响 (r(2) < 0.15)。儿童和成人处理语义语言流畅性的大脑区域是相似的。激活的偏侧性不会随着年龄的增长而明显改变，并且在 7 岁时似乎出现强烈的偏侧化。哼。大脑图谱 18:176-185,2003。 2003 年出版 Wiley-Liss, Inc.
We examined developmental differences, in location and extent of fiviRI language activation maps, between adults and children while performing a semantic fluency task. We studied 29 adults and 16 children with echo planar imaging BOLD fMRI at 1.5 T using covert semantic verbal fluency (generation of words to categories compared to rest) using a block design. Post task testing was administered to assess performance. Individual data were analyzed with an a priori region of interest approach from t maps (t = 4) and asymmetry indices (AI). Group studies were analyzed using SPM 99 (Wellcome, UK; fixed effect, corrected P < 0.0001). We found no significant differences in location or laterality of activation between adults and children for a semantic verbal fluency task. Adults activated more pixels than children in left inferior frontal gyrus and left middle frontal gyrus, but AIs were the similar across ages (r(2) < 0.09). Extent or laterahty of activation was not affected by performance (r(2) < 0.15). The brain areas that process semantic verbal fluency are similar in children and adults. The laterality of activation does not change appreciably with age and appears to be strongly lateralized by age 7 years. Hum. Brain Mapping 18:176-185,2003. Published 2003 Wiley-Liss, Inc.