Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD.
Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD.
复制标题
DOI：
10.1038/srep41709
复制
发表时间：
2017-02-08
影响因子：
4.6
通讯作者：
Suda T
中科院分区：
文献类型：
--
作者：
Karayama M;Inui N;Mori K;Kono M;Hozumi H;Suzuki Y;Furuhashi K;Hashimoto D;Enomoto N;Fujisawa T;Nakamura Y;Watanabe H;Suda T
受迫振荡技术提供有关呼吸阻抗的信息，其中包括呼吸系统的电阻和电抗。然而，其与慢性阻塞性肺疾病（COPD）肺部形态变化的关系仍不清楚。对 98 名 COPD 患者和 49 名参考受试者的呼吸阻抗和肺量测定数据进行了评估。使用三维计算机断层扫描测量第三代至第六代支气管的壁厚度（WT）和气道腔内面积（Ai）以及肺小于-950 HU（％LAA）的低衰减区域百分比。与参考受试者相比，COPD 患者呼吸阻抗较高、Ai 降低、%LAA 增加。呼吸阻力和电抗指数以及 1 秒用力呼气量 (FEV1) 与 Ai 相关，并且预测 FEV1 百分比与 Ai 之间的关联在远端支气管中占主导地位。 5赫兹和20赫兹之间的呼吸阻力差异（R5-R20）和FEV1/用力肺活量比（FEV1/FVC）与WT相关。 %LAA 与 FEV1/FVC 比值和呼吸电抗相关。使用受迫振荡技术进行的气道功能测量为慢性阻塞性肺病 (COPD) 中的肺活量测定提供了补充信息。
The forced oscillation technique provides information concerning respiratory impedance, which comprises resistance and reactance of the respiratory system. However, its relationship with morphological changes of the lungs in chronic obstructive pulmonary disease (COPD) remains unclear. Respiratory impedance and spirometric data were evaluated in 98 patients with COPD and 49 reference subjects. Wall thickness (WT) and airway intraluminal area (Ai) of third- to sixth-generation bronchi, and percentage low-attenuation area with less than −950 HU (%LAA) of lungs were measured using three-dimensional computed tomography. COPD patients had higher respiratory impedance, decreased Ai, and increased %LAA compared with reference subjects. Indices of respiratory resistance and reactance and forced expiratory volume in 1 second (FEV1) were correlated with Ai, and the association between percent predicted FEV1 and Ai was predominant in distal bronchi. The difference in respiratory resistance between 5 Hz and 20 Hz (R5–R20) and FEV1/forced vital capacity ratio (FEV1/FVC) were correlated with WT. The %LAA was correlated with the FEV1/FVC ratio and respiratory reactance. Airway function measurements with the forced oscillation technique provide complementary information to spirometry in COPD.