Thyroid hormone modulation during zebrafish development recapitulates evolved diversity in danionin jaw protrusion mechanics
Thyroid hormone modulation during zebrafish development recapitulates evolved diversity in danionin jaw protrusion mechanics
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DOI：
10.1111/ede.12299
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发表时间：
2019-08-02
影响因子：
2.9
通讯作者：
Cooper, W. James
中科院分区：
文献类型：
--
作者：
Galindo, Demi;Sweet, Elly;Cooper, W. James
突出的下巴是一个非常有用的创新，已联系到广泛的多样化鱼类饲养生态。下颌前伸可以增强多种功能的表现，如产生吸力和捕获难以捉摸的猎物。识别改变突出能力的发育因素将提高我们对鱼类多样化的理解。在斑马鱼的突起出现postmorphosis。鱼类变态通常包括营养形态的显着变化，伴随着摄食生态位的转变，并与甲状腺激素的产生增加相一致。我们测试了甲状腺激素是否影响斑马鱼摄食机制的发展。我们发现，它影响了所有的发育阶段检查，但效果最明显的变态后。甲状腺激素水平影响颌骨形态、摄食机制、形状变化和颅骨骨化的发育。成年斑马鱼利用无牙颌，但甲状腺激素的缺乏损害了前颌骨的发育，这对颌骨突出至关重要。早期幼年斑马鱼和甲状腺功能减退成年斑马鱼的前颌骨与Danionella、Devario和Microdevario属的成年斑马鱼的前颌骨相似，几乎没有或没有下颌突出。我们的研究结果表明，进化的变化如何发展的头骨danionin小鱼甲状腺激素的反应可能促进了多样化到不同的喂养生态位。
Protrusile jaws are a highly useful innovation that has been linked to extensive diversification in fish feeding ecology. Jaw protrusion can enhance the performance of multiple functions, such as suction production and capturing elusive prey. Identifying the developmental factors that alter protrusion ability will improve our understanding of fish diversification. In the zebrafish protrusion arises postmetamorphosis. Fish metamorphosis typically includes significant changes in trophic morphology, accompanies a shift in feeding niche and coincides with increased thyroid hormone production. We tested whether thyroid hormone affects the development of zebrafish feeding mechanics. We found that it affected all developmental stages examined, but that effects were most pronounced after metamorphosis. Thyroid hormone levels affected the development of jaw morphology, feeding mechanics, shape variation, and cranial ossification. Adult zebrafish utilize protrusile jaws, but an absence of thyroid hormone impaired development of the premaxillary bone, which is critical to jaw protrusion. Premaxillae from early juvenile zebrafish and hypothyroid adult zebrafish resemble those from adults in the genera Danionella, Devario, and Microdevario that show little to no jaw protrusion. Our findings suggest that evolutionary changes in how the developing skulls of danionin minnows respond to thyroid hormone may have promoted diversification into different feeding niches.