Effects of diazepam on BOLD activation during the processing of aversive faces
Effects of diazepam on BOLD activation during the processing of aversive faces
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DOI：
10.1177/0269881110389092
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发表时间：
2012-04-01
影响因子：
4.1
通讯作者：
Graeff, Frederico G.
中科院分区：
文献类型：
--
作者：
Del-Ben, Cristina M.;Ferreira, Cesar A. Q.;Graeff, Frederico G.
本研究的目的是测量，使用功能磁共振成像，地西泮对血流动力学反应的情绪面孔的影响。12名健康男性志愿者（平均年龄= 24.83 +/- 3.16岁）采用随机、平衡顺序、双盲、安慰剂对照交叉设计进行评价。在神经影像学采集前1小时给予地西泮（10 mg）或安慰剂。在一个封闭设计的内隐面孔情绪任务中，被试被呈现中性（A）和厌恶（B）（愤怒或恐惧）的面孔。参与者还提交了一个明确的情感面部识别任务，并在整个过程中评估主观焦虑。地西泮减弱了恐惧面孔对右侧杏仁核和右侧眶额皮质的激活，增强了右侧前扣带皮质（ACC）的激活。与此相反，地西泮增强激活的左后额叶和衰减激活的双侧ACC愤怒的面孔。在行为任务中，地西泮损害了女性面孔中恐惧的识别。在地西泮的作用下，志愿者在实验结束时的焦虑程度降低。这些结果表明，苯二氮卓类药物可以差异调节大脑激活厌恶刺激，这取决于刺激的功能，并表明杏仁核和杏仁核的作用，在苯二氮卓类药物的抗焦虑作用。
This study aimed to measure, using fMRI, the effect of diazepam on the haemodynamic response to emotional faces. Twelve healthy male volunteers (mean age = 24.83 +/- 3.16 years), were evaluated in a randomized, balanced-order, double-blind, placebo-controlled crossover design. Diazepam (10 mg) or placebo was given 1 h before the neuroimaging acquisition. In a blocked design covert face emotional task, subjects were presented with neutral (A) and aversive (B) (angry or fearful) faces. Participants were also submitted to an explicit emotional face recognition task, and subjective anxiety was evaluated throughout the procedures. Diazepam attenuated the activation of right amygdala and right orbitofrontal cortex and enhanced the activation of right anterior cingulate cortex (ACC) to fearful faces. In contrast, diazepam enhanced the activation of posterior left insula and attenuated the activation of bilateral ACC to angry faces. In the behavioural task, diazepam impaired the recognition of fear in female faces. Under the action of diazepam, volunteers were less anxious at the end of the experimental session. These results suggest that benzodiazepines can differentially modulate brain activation to aversive stimuli, depending on the stimulus features and indicate a role of amygdala and insula in the anxiolytic action of benzodiazepines.