Treatment of poorly regulated non-insulin-dependent diabetes mellitus with combination insulin-sulfonylurea.
Treatment of poorly regulated non-insulin-dependent diabetes mellitus with combination insulin-sulfonylurea.
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用胰岛素-磺酰脲类药物联合治疗调节不佳的非胰岛素依赖型糖尿病。
DOI：
10.1001/archinte.1985.00360100170028
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发表时间：
1985
影响因子：
--
通讯作者：
H. Lebovitz
中科院分区：
文献类型：
--
作者：
B. Allen;M. Feinglos;H. Lebovitz
非胰岛素依赖型糖尿病（NIDDM）的特征是肝脏葡萄糖产生增加和外周葡萄糖摄取不足。1这些葡萄糖代谢紊乱被认为是由于细胞对胰岛素作用的抵抗和胰岛素分泌不足造成的。2，3细胞对胰岛素作用的抵抗是由胰岛素作用的一个或多个后受体位点的紊乱引起的。4，5确实会发生胰岛素结合减少，但认为这是由于基础血浆胰岛素水平升高继发的胰岛素受体下调所致。5不能排除NIDDM患者胰岛素受体的少量直接减少是胰岛素抵抗的一个原因。非胰岛素依赖型糖尿病患者的β细胞不能对葡萄糖做出适当的反应而分泌胰岛素。3这种异常可能是细胞内紊乱的结果，导致葡萄糖介导的胰岛素分泌延迟和不足。6随着空腹高血糖水平的增加，β细胞葡萄糖介导的胰岛素
Non–insulin-dependent diabetes mellitus (NIDDM) is characterized by increased hepatic glucose production and deficient peripheral glucose uptake. 1 These disturbances in glucose metabolism are thought to result from cellular resistance to insulin action and deficient secretion of insulin. 2,3 The cellular resistance to insulin action is caused by disturbances in one or more postreceptor sites of insulin action. 4,5 Decrease in insulin binding does occur, but it is thought to be due to down-regulation of the insulin receptor secondary to the increased basal plasma insulin levels. 5 A small direct decrease in insulin receptors in NIDDM cannot be excluded as a contributory cause to the insulin resistance. The β cell in patients with NIDDM does not secrete insulin appropriately in response to glucose. 3 This abnormality is likely the result of an intracellular disturbance and results in delayed as well as insufficient glucose-mediated insulin secretion. 6 As the level of fasting hyperglycemia increases, β-cell glucose-mediated insulin
胰岛素受体及其在碳水化合物耐受性临床疾病中的作用。
DOI：
10.1016/0002-9343(83)90249-8
发表时间：
1983
期刊：
The American journal of medicine
影响因子：
--
作者：
Pollet,RJ
通讯作者：
Pollet,RJ
胰岛素受体的细胞信号传导。
影响因子：
16.2
作者：
Czech,MP;Yu,KT;Seals,JR
通讯作者：
Seals,JR