Enhancement of the treatment of experimental candidiasis with vascular decongestants.
Enhancement of the treatment of experimental candidiasis with vascular decongestants.
复制标题
用血管减充血剂增强实验性念珠菌病的治疗。
DOI：
10.1093/infdis/162.1.211
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Lopez-Berestein,G
中科院分区：
文献类型：
--
作者：
Luke,DR;Wasan,KM;McQueen,TJ;Lopez-Berestein,G
The mechanism of amphotericin B (AmB) nephrotoxicity may be related to changes in vascular flow within the kidney, resulting in significant decreases in glomerular filtration rate and tubular integrity. The toxic and antifungal effects of AmB with and without the vascular decongestants pentoxifylline (PIX) and a methylxanthine analog, HWA-138, were compared in the murine model of candidiasis. At 48 h after inoculation withCandida albicans, half of the rats received a single intravenous 0.8 mg/kg dose of AmB whereas the others were administered sterile water. After 1 h, rats wererandomized to receivethree doses of 45 mg/kg PIX intraperitoneally, 5 mg/kg HWA-138 intravenously, or saline every 12 h. Renal function andCandidacell counts were estimated 24 h after AmB administration. Mean inulin clearances were significantly greater in rats coadministered AmB and PTX or HWA-138 than in AmB controls.Candidacounts in kidneys of rats administered HWA-138 were similar independent of AmB therapy and markedly reduced compared with other groups. Whereas both vascular decongestants prevented drugassociated renal toxicity, the coadministration of AmB with HWA-138 resulted in a profound antifungal effect.
