wingless inhibits morphogenetic furrow movement in the Drosophila eye disc.
wingless inhibits morphogenetic furrow movement in the Drosophila eye disc.
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DOI：
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发表时间：
1995-11
期刊：
影响因子：
4.6
通讯作者：
J. Treisman;Gerald M. Rubin
中科院分区：
文献类型：
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作者：
J. Treisman;Gerald M. Rubin
果蝇眼睛想象盘的分化是一个不同步的、重复的过程，从后到前穿过整个盘。它的传播与分化前沿、形态发生沟中的十足瘫痪的表达有关。分化和截瘫的表达都是由沟后分化的细胞分泌的Hedgehog蛋白维持的。然而，由于未知的机制，它们在后缘发生在Hedgehog表达之前。我们在这里证明了无翼基因有助于启动的正确空间定位。形态发生沟的启动被限制在后缘，因为侧缘存在无翼；去除无翼允许侧向启动。在后缘异位表达的无翼也可以抑制正常的启动。此外，椎盘中央的无翼可以防止皱纹的进展。这些无翼的效果是在不改变十足瘫痪的表现的情况下实现的。
Differentiation of the Drosophila eye imaginal disc is an asynchronous, repetitive process which proceeds across the disc from posterior to anterior. Its propagation correlates with the expression of decapentaplegic at the front of differentiation, in the morphogenetic furrow. Both differentiation and decapentaplegic expression are maintained by Hedgehog protein secreted by the differentiated cells posterior to the furrow. However, their initiation at the posterior margin occurs prior to hedgehog expression by an unknown mechanism. We show here that the wingless gene contributes to the correct spatial localization of initiation. Initiation of the morphogenetic furrow is restricted to the posterior margin by the presence of wingless at the lateral margins; removal of wingless allows lateral initiation. Ectopic expression of wingless at the posterior margin can also inhibit normal initiation. In addition, the presence of wingless in the center of the disc can prevent furrow progression. These effects of wingless are achieved without altering the expression of decapentaplegic.