Synthesis of Stereoselectively Functionalized Silacyclopentanes
Synthesis of Stereoselectively Functionalized Silacyclopentanes
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DOI：
10.1055/s-0036-1590826
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发表时间：
2017-11-01
期刊：
影响因子：
2
通讯作者：
Tomooka, Katsuhiko
中科院分区：
文献类型：
--
作者：
Igawa, Kazunobu;Kuroo, Akihiro;Tomooka, Katsuhiko
通过Mitsunobu反应和Tsuji-Trost反应，硅环戊烯醇的C4碳立体异构中心发生了有规立构的转化，发展了一种合成具有硅立体异构中心的手性硅环戊烷的有效方法。由此获得的取代产物可以立体定向方式转化为新的硅杂环戊烷三醇、胺和羧酸。
An efficient approach to a variety of chiral silacyclopentanes having silicon stereogenic center based on the stereospecific transformations of C4 carbon stereogenic center of silacyclopentenols by Mitsunobu reaction or Tsuji-Trost reaction has been developed. The thus obtained substitution products can be converted into novel silacyclopentane triols, amines, and carboxylic acids in stereospecific manner.