A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation
A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation
复制标题
红光照射下具有 PACT、光氧化还原催化和 PDT 三重功能的 Ru-蒽醌二元体
DOI：
10.1039/d1dt01088c
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发表时间：
2021
影响因子：
4
通讯作者：
Zhou Qianxiong
中科院分区：
文献类型：
--
作者：
Zhang Chao;Guo Xusheng;Da Xuwen;Wang Zhanhua;Wang Xuesong;Zhou Qianxiong
近年来，用于癌症治疗的光疗法受到了广泛关注，其中在照射后具有多种抗癌机制的化合物尤其引人注目。在这项工作中，硝基蒽醌基团连接到基于biq（2,2'-联喹啉）配体的Ru（II）配合物上，赋予所得的Ru1化合物在600 nm光照射下具有多种抗癌机制。 Ru1 可以发生 biq 配体光解，显示出其作为光活化化疗 (PACT) 药物的潜力。此外，照射后可产生Ru(III)中心和蒽醌阴离子中心，进一步氧化NADH/NADPH并生成O2˙−，成功引发光氧化还原催化和光动力治疗（PDT）。与不含硝基蒽醌基团的对照复合物 Ru2 相比，Ru1 在红光照射下对一系列癌细胞系和 3D 多细胞球体表现出增强的光细胞毒性。
Phototherapy for cancer treatment has received much attention in recent years, and compounds with multiple anticancer mechanisms upon irradiation are particularly appealing. In this work, a nitro-anthraquinone group was attached to a biq (2,2′-biquinoline) ligand based Ru(II) complex, endowing the resultant Ru1 compound with multiple anticancer mechanisms upon 600 nm light irradiation. Ru1 can undergo biq ligand photodissociation, showing its potential as a photoactivated chemotherapy (PACT) agent. Moreover, a Ru(III) centre and an anthraquinone anion centre may be generated upon irradiation, which can further oxidize NADH/NADPH and generate O2˙−, successfully eliciting photoredox catalysis and photodynamic therapy (PDT). Compared to the control complex Ru2 without the nitroanthraquinone group, Ru1 exhibited much enhanced photocytotoxicity towards a series of cancer cell lines and 3D multicellular spheroids upon red light irradiation.