The primate thalamostriatal systems: Anatomical organization, functional roles and possible involvement in Parkinson's disease.
The primate thalamostriatal systems: Anatomical organization, functional roles and possible involvement in Parkinson's disease.
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DOI：
10.1016/j.baga.2011.09.001
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发表时间：
2011-11-01
期刊：
影响因子：
--
通讯作者：
Smith, Yoland
中科院分区：
文献类型：
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作者：
Galvan, Adriana;Smith, Yoland
纹状体接收来自两个主要丘脑-纹状体系统的丘脑-纹状体能输入，这两个系统起源于中央正中/束旁复合体（CM/PF-纹状体系统）或头侧板内、中线、联合和中继丘脑核（非CM/PF-纹状体系统）。这些双丘脑纹状体系统显示其解剖结构和最有可能的功能组织的显着差异。CM/PF-纹状体系统的地形组织，并集成在功能分离的基底神经节丘脑纹状体电路，处理感觉运动，联想和边缘系统的信息。CM/PF神经元对注意力相关的感觉刺激具有高度反应性，这表明CM/PF-纹状体系统通过其与胆碱能中间神经元的强连接，可能在基底神经节介导的学习、行为转换和强化中发挥作用。根据帕金森病中突出的CM/PF神经元丢失的证据，我们提出，显著的CM-纹状体系统变性，结合感觉运动纹状体区域中严重的黑质纹状体多巴胺丢失，可能会改变正常的自动动作，并将基底神经节-丘脑皮质运动程序的处理转向目标导向行为。
The striatum receives glutamatergic inputs from two main thalamostriatal systems that originate either from the centre median/parafascicular complex (CM/PF-striatal system) or the rostral intralaminar, midline, associative and relay thalamic nuclei (non-CM/PF-striatal system). These dual thalamostriatal systems display striking differences in their anatomical and, most likely, functional organization. The CM/PF-striatal system is topographically organized, and integrated within functionally segregated basal ganglia-thalamostriatal circuits that process sensorimotor, associative and limbic information. CM/PF neurons are highly responsive to attention-related sensory stimuli, suggesting that the CM/PF-striatal system, through its strong connections with cholinergic interneurons, may play a role in basal ganglia-mediated learning, behavioral switching and reinforcement. In light of evidence for prominent CM/PF neuronal loss in Parkinson’s disease, we propose that the significant CM-striatal system degeneration, combined with the severe nigrostriatal dopamine loss in sensorimotor striatal regions, may alter normal automatic actions, and shift the processing of basal ganglia-thalamocortical motor programs towards goal-directed behaviors.