Consuming fructose-sweetened beverages increases body adiposity in mice
Consuming fructose-sweetened beverages increases body adiposity in mice
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DOI：
10.1038/oby.2005.136
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发表时间：
2005-07-01
期刊：
影响因子：
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通讯作者：
Tschöp, MH
中科院分区：
文献类型：
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作者：
Jürgens, H;Haass, W;Tschöp, MH
目的：美国肥胖患病率显着增加最近归因于果糖消费量的增加。为了确定果糖是否以及如何在动物模型中促进肥胖，我们测量了摄入果糖的小鼠的身体成分、能量摄入、能量消耗、底物氧化以及与能量稳态相关的几个内分泌参数。研究方法和程序：我们比较了随意摄入果糖（15%水溶液）、蔗糖（10%，流行软饮料）和人工甜味剂（0%卡路里，流行减肥软饮料）对脂肪生成的影响结果：接触果糖水会增加肥胖，而饮用软饮料后脂肪量的增加并未达到统计学显着性（每组 n = 9）。能量的总摄入量没有改变，因为小鼠从食物中摄入的热量按比例减少。果糖组有能量消耗减少和呼吸商增加的趋势，尽管并不显着。此外，果糖产生具有特征性的中央周围模式的肝脂质积累。讨论：这些数据与以下结论相一致：大量摄入果糖可能通过将底物用途转变为脂肪生成来选择性地增强脂肪生成。
Objective: The marked increase in the prevalence of obesity in the United States has recently been attributed to the increased fructose consumption. To determine if and how fructose might promote obesity in an animal model, we measured body composition, energy intake, energy expenditure, substrate oxidation, and several endocrine parameters related to energy homeostasis in mice consuming fructose.Research Methods and Procedures: We compared the effects of ad libitum access to fructose (15% solution in water), sucrose (10%, popular soft drink), and artificial sweetener (0% calories, popular diet soft drink) on adipogenesis and energy metabolism in mice.Results: Exposure to fructose water increased adiposity, whereas increased fat mass after consumption of soft drinks diet soft drinks did not reach statistical significance (n = 9 each group). Total intake of energy was unaltered, because mice proportionally reduced their caloric intake from chow. There was a trend toward reduced energy expenditure and increased respiratory quotient, albeit not significant, in the fructose group. Furthermore, fructose produced a hepatic lipid accumulation with a characteristic pericentral pattern.Discussion: These data are compatible with the conclusion that a high intake of fructose selectively enhances adipogenesis, possibly through a shift of substrate use to lipogenesis.