Endotoxin exposure as a major determinant of lung function decline in pig farmers
Endotoxin exposure as a major determinant of lung function decline in pig farmers
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DOI：
10.1164/ajrccm.157.1.9703087
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发表时间：
1998-01-01
影响因子：
24.7
通讯作者：
van Schayck, CP
中科院分区：
文献类型：
--
作者：
Vogelzang, PFJ;van der Gulden, JWJ;van Schayck, CP
研究了粉尘中内毒素的暴露-反应关系和肺功能的纵向下降。对171名养猪户进行了为期3年的随访。长期平均暴露于灰尘和内毒素，确定在夏季和冬季的个人监测，使用数据的农场特征和活动。FEV平均下降73 ml/年，FVC平均下降55 ml/年。长期平均接触粉尘为2.63 mg/m3（几何SD [CSD] 1.30），接触内毒素为105 ng/m3（CSD 1.5）。FEV 1的年下降与内毒素暴露显著相关。因子2的暴露增加与FEV 1额外下降19 ml/yr相关。
Exposure-response relationships for endotoxin as measured in dust and longitudinal decline in lung function were studied. A cohort of 171 pig farmers was followed over a 3-yr period. Long-term average exposure to dust and endotoxin was determined by personal monitoring in summer and winter, using data on farm characteristics and activities. Mean decline in FEV, was 73 ml/yr and in FVC 55 ml/yr. Long-term average exposure to dust was 2.63 mg/m(3) (geometric SD [CSD] 1.30), and to endotoxin, 105 ng/m(3) (CSD 1.5). Annual decline in FEV1 was significantly associated with endotoxin exposure. An increase in exposure with a factor 2 was associated with an extra decline of FEV1 of 19 ml/yr.