A discrete neuronal circuit induces a hibernation-like state in rodents
A discrete neuronal circuit induces a hibernation-like state in rodents
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DOI：
10.1038/s41586-020-2163-6
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发表时间：
2020-07-02
期刊：
影响因子：
64.8
通讯作者：
Sakurai, Takeshi
中科院分区：
文献类型：
--
作者：
Takahashi, Tohru M.;Sunagawa, Genshiro A.;Sakurai, Takeshi
冬眠哺乳动物在面临食物短缺时，会主动降低体温以减少能量消耗(1)。由于其潜在的医疗益处，这种诱导低代谢状态的能力引起了极大的兴趣(2，3)。在这里，我们展示了啮齿类动物的下丘脑神经元回路导致类似冬眠的长期低温和低代谢状态。在这种状态下，尽管体温和耗氧量保持在很低的水平，但调节新陈代谢的能力仍然有效，就像在冬眠中一样。从这种状态恢复后，对组织器官没有明显的损害，也没有行为异常。我们的发现可能使开发一种诱导类冬眠状态的方法成为可能，这将在包括人类在内的非冬眠哺乳动物物种中具有潜在的应用。
Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity(1). This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits(2,3). Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation(4). There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.