Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum
Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum
复制标题
谷氨酸二乙酯对纹状体神经元皮质兴奋的拮抗作用：谷氨酸作为大鼠纹状体兴奋性递质的证据
DOI：
10.1016/0006-8993(76)90577-1
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发表时间：
1976
期刊：
影响因子：
2.9
通讯作者：
Hugh J. Spencer
中科院分区：
文献类型：
--
作者：
Hugh J. Spencer
受皮质刺激刺激的大鼠纹状体细胞对皮质刺激的反应平均潜伏期为12毫秒。每个反应都包含一个可变数量的尖峰，平均而言，刺激和产生的尖峰数量之间的关系小于1:1。谷氨酸二乙酯（GDEE）是一种谷氨酸拮抗剂，在+50 ~ +125 nA的电流下，在受皮层刺激兴奋的神经元附近离子电泳，几乎完全抑制了90%的细胞的兴奋，并且这种抑制是完全可逆的。所有细胞都被谷氨酸兴奋。GDEE还能抑制天冬氨酸、谷氨酸和dl-同型半胱氨酸引起的神经元兴奋。本研究认为，一种兴奋性氨基酸（天冬氨酸或谷氨酸）可能在皮质酸盐投射中起递质作用。
Rat striatal cells that were excited by cortical stimulation were found to respond to cortical stimulation with an average latency of 12 msec. Each response consisted of a variable number of spikes with, on the average, a less than 1:1 relationship between the stimulus and the number of spikes generated.Iontophoretic application of glutamic acid diethyl ester (GDEE), a substance reported to be a glutamate antagonist, at currents of +50 to +125 nA in the vicinity of neurons excited by cortical stimulation, almost totally suppressed the excitation in 90% of the cells, and this suppression was fully reversible. All cells were excited by glutamate. GDEE also suppressed neuronal excitation produced by iontophoretic aspartate, glutamate anddl-homocysteic acid.It is concluded from this study that an excitatory amino acid, either aspartic or glutamic, may function as the transmitter in the corticostriate projection.