Predictive factors for the development of persistent pain after breast cancer surgery
Predictive factors for the development of persistent pain after breast cancer surgery
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DOI：
10.1097/j.pain.0000000000000298
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发表时间：
2015-12-01
期刊：
影响因子：
7.4
通讯作者：
Kehlet, Henrik
中科院分区：
文献类型：
--
作者：
Andersen, Kenneth Geving;Duriaud, Helle Molter;Kehlet, Henrik
先前的研究报告称，15% 至 25% 的乳腺癌患者在手术部位会经历长期的中度至重度疼痛，可能持续数年。很少有前瞻性研究涵盖了乳腺癌术后（PPBCS）发生持续性疼痛的所有潜在危险因素。这项前瞻性队列研究的目的是全面确定预测 PPBCS 的因素。招募了计划进行原发性乳腺癌手术的患者。评估在术前、术后前 3 天、术后 1 周、6 个月和 1 年进行。使用了经过验证的综合调查问卷。外科医生记录了肋间臂神经的处理情况。对术后前 3 周已知的因素进行序数逻辑回归分析建模。纳入了 537 名具有基线数据的患者，其中 475 名 (88%) 患者可在 1 年时进行分析。 1 年随访时，休息时中度至重度疼痛的发生率为 14%，运动时为 7%。与休息时疼痛相关的因素是年龄
Previous studies have reported that 15% to 25% of patients treated for breast cancer experience long-term moderate-to-severe pain in the area of surgery, potentially lasting for several years. Few prospective studies have included all potential risk factors for the development of persistent pain after breast cancer surgery (PPBCS). The aim of this prospective cohort study was to comprehensively identify factors predicting PPBCS. Patients scheduled for primary breast cancer surgery were recruited. Assessments were conducted preoperatively, the first 3 days postoperatively, and 1 week, 6 months, and 1 year after surgery. A comprehensive validated questionnaire was used. Handling of the intercostobrachial nerve was registered by the surgeon. Factors known by the first 3 weeks after surgery were modeled in ordinal logistic regression analyses. Five hundred thirty-seven patients with baseline data were included, and 475 (88%) were available for analysis at 1 year. At 1-year follow-up, the prevalence of moderate-to-severe pain at rest was 14% and during movement was 7%. Factors associated with pain at rest were age