The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension
The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension
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DOI：
10.1111/jch.13002
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发表时间：
2017-08-01
影响因子：
2.8
通讯作者：
Qiu, Zhiling
中科院分区：
文献类型：
--
作者：
Wang, Huan;Hu, Yuanhui;Qiu, Zhiling
最近，中性粒细胞/淋巴细胞比值（NLR）已被证明是炎症和心血管风险的有用指标。臂踝脉搏波速度是早期动脉粥样硬化变化的指标。 NLR在不同高血压亚型中是否存在差异尚不清楚，并且对于不同亚型高血压中NLR与动脉硬化的关系也鲜有研究。写这篇文章的目的就是为了探究他们之间的关系。总共纳入了 217 名连续高血压患者和 132 名无高血压患者。所有高血压患者根据诊室血压分为三组。与血压正常的对照组相比，单纯性收缩期高血压、单纯性舒张期高血压以及收缩期和舒张期高血压患者的臂踝脉搏波速度升高。单纯收缩期高血压以及收缩期和舒张期高血压患者的 NLR 高于血压正常对照者。相关分析显示NLR与臂踝脉搏波速度呈正相关。多元线性回归分析显示NLR是臂踝脉搏波速度的有效指标。
Recently, neutrophil/lymphocyte ratio (NLR) has been proved to be a useful indicator of inflammation and cardiovascular risk. Brachial-ankle pulse wave velocity is an indicator for early atherosclerotic changes. It is unknown whether NLR differs in subtypes of hypertension, and little research has been performed on the relationship between NLR and arteriosclerosis in subtypes of hypertension. The purpose of this article was to investigate their relationship. A total of 217 consecutive patients with hypertension and 132 persons without hypertension were included. All hypertension patients were divided into three groups according to office blood pressure. Brachial-ankle pulse wave velocity was elevated in patients with isolated systolic hypertension, isolated diastolic hypertension, and systolic and diastolic hypertension compared with normotensive controls. NLR in patients with isolated systolic hypertension and systolic and diastolic hypertension were higher than in normotensive controls. Correlation analysis revealed a positive correlation between NLR and brachial-ankle pulse wave velocity. Multivariate linear regression analysis showed that NLR was an effective indicator for brachial-ankle pulse wave velocity.