Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes
Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes
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DOI：
10.2337/dc06-0637
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发表时间：
2006-10-01
期刊：
影响因子：
16.2
通讯作者：
Dandona, Paresh
中科院分区：
文献类型：
--
作者：
Bhatia, Vishal;Chaudhuri, Ajay;Dandona, Paresh
目的：在证实三分之一的男性2型糖尿病患者患有低促性腺激素性性腺功能减退症后，我们发现低促性腺激素性性腺功能减退症患者的C反应蛋白（CRP）浓度也显著升高。我们现在假设，2型糖尿病患者低促性腺激素性腺功能减退症可能有一个塔红细胞压积，因为睾酮刺激，而慢性炎症抑制，erythropoies.RESEARCH设计和方法-七十例2型糖尿病患者在三级转诊center.RESULTS纳入本研究的平均红细胞压积低促性腺激素性腺功能减退症患者（n = 37），定义为计算的游离睾酮（cFT）< 6.5 ng/dl，为40.6 +/-1.1%，而性腺功能正常的患者（n = 33）为43.3 +/- 0.7%（P = 0.011）。红细胞压积与cFT浓度相关（r = 0.46，P < 0.0001），与血浆CRP浓度呈负相关（r = 0.41，P < 0.0004）。CRP < 3 mg/l患者的红细胞压积（42.7 +/- 0.7%）高于CRP > 3 mg/l患者（39.9 +/- 1.1%; P < 0.05）。正常红细胞正常色素性贫血（血红蛋白< 13 g/dl）的患病率在整个组中为23%，而在低促性腺激素性腺功能减退症男性中为37.8%，在性腺功能正常男性中为3%（P < 0.01）。促红细胞生成素浓度升高或高正常在所有I I贫血患者中，它是tested.CONCLUSIONS -我们得出结论，低促性腺激素性腺功能减退症男性2型糖尿病患者与较低的红细胞压积和经常发生的轻度正常红细胞色素正常性贫血与正常或高促红细胞生成素浓度。在这些患者中，红细胞压积也与CRP浓度呈负相关。因此，低睾酮和慢性炎症机制可能导致轻度贫血。鉴于这些患者的CRP浓度显著升高，他们也可能具有动脉粥样硬化性心血管事件的高风险。
OBJECTIVE - After the demonstration that one-third of male patients with type 2 diabetes have hypogonadotrophic hypogonadism, we have shown that patients with hypogonadotrophic hypogonadism also have markedly elevated C-reactive protein (CRP) concentrations. We have now hypothesized that type 2 diabetic subjects with hypogonadotrophic hypogonadism may have a tower hematocrit because testosterone stimulates, whereas chronic inflammation suppresses, erythropoiesis.RESEARCH DESIGN AND METHODS - Seventy patients with type 2 diabetes at a tertiary referral center were included in this study.RESULTS - The mean hematocrit in patients with hypogonadotrophic hypogonadism (n = 37), defined as calculated free testosterone (cFT) of < 6.5 ng/dl, was 40.6 +/- 1.1%, whereas that in eugonadal patients (n = 33) was 43.3 +/- 0.7% (P = 0.011). The hematocrit was related to cFT concentration (r = 0.46; P < 0.0001); it was inversely related to plasma CRP concentration (r = 0.41 P < 0.0004). Patients with CRP < 3 mg/l had a higher hematocrit (42.7 +/- 0.7%) than those with CRP > 3 mg/l (39.9 +/- 1.1%; P < 0.05). The prevalence of normocytic normochromic anemia (hemoglobin < 13 g/dl) was 23% in the entire group, whereas it was 37.8% in the men with hypogonadotrophic hypogonadism and 3% in the eugonadal men (P < 0.01). Erythropoietin concentration was elevated or high normal in all I I patients with anemia in whom it was tested.CONCLUSIONS - We conclude that hypogonadotrophic hypogonadism in male type 2 diabetic subjects is associated with a lower hematocrit and a frequent occurrence of mild normocytic normochromic anemia with normal or high erythropoietin concentrations. In these patients, hematocrit is also inversely related to CRP concentration. Thus, low testosterone and chronic inflammatory mechanisms may contribute to mild anemia. Such patients may also have a high risk of atherosclerotic cardiovascular events in view of their markedly elevated CRP concentrations.