Discovery of Cyclic Diarylheptanoids as Inhibitors against Influenza A Virus from the Roots of Casuarina equisetifolia.
Discovery of Cyclic Diarylheptanoids as Inhibitors against Influenza A Virus from the Roots of Casuarina equisetifolia.
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DOI：
10.1021/acs.jnatprod.2c00335
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发表时间：
2022-08
影响因子：
5.1
通讯作者：
Xiaoyu Xu;Liurong Chen;Yucai Luo;Ruanling Gao;Yingting Xu;Jie Yang;Zhongyue Zhou;Xiaoyi Wei
中科院分区：
文献类型：
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作者：
Xiaoyu Xu;Liurong Chen;Yucai Luo;Ruanling Gao;Yingting Xu;Jie Yang;Zhongyue Zhou;Xiaoyi Wei
从木麻黄属植物木麻黄（Casuarina equisetifolia）的根中分得4个新的环状二芳基庚烷类化合物，即木麻黄醇A ~ C（1-3）和木麻黄醇A（4），以及6个已知化合物（5-10）。通过广泛的光谱分析、理论构象和电子圆二色谱分析阐明了结构。木麻黄酚C（3）是一种新型的环状二芳基庚醛加合物。木麻黄素A（4）表示开环二芳基庚烷类化合物的第一结构。评价化合物1-9针对A/WSN/33（H1N1）的抗甲型流感病毒（IAV）活性。（-）-（M）-11-氧代-3，12R，17-三羟基-9-烯-[7，0]-间环蕃（5）具有明显的抗IAV活性，IC_（50）为8.64 ± 2.49 μM，CC_（50）大于100 μM。
Four new cyclic diarylheptanoids, casuarinols A-C (1-3) and casuarinolide A (4), together with six known ones (5-10), were isolated from the roots of Casuarina equisetifolia. Structures were elucidated by extensive spectroscopic analysis, theoretical conformational, and electronic circular dichroism analyses. Casuarinol C (3) is a novel cyclic diarylheptanoid-aldehyde adduct. Casuarinolide A (4) represents the first structure of a seco-cyclic diarylheptanoid. Compounds 1-9 were evaluated for their anti-influenza A virus (IAV) activity against A/WSN/33 (H1N1). (-)-(M)-11-Oxo-3,12R,17-trihydroxy-9-ene-[7,0]-metacyclophane (5) displayed significant anti-IAV activity with an IC50 value of 8.64 ± 2.49 μM and a CC50 higher than 100 μM.