Complementary oligonucleotides and the origin of the mammalian involucrin gene.
Complementary oligonucleotides and the origin of the mammalian involucrin gene.
复制标题
互补寡核苷酸和哺乳动物外皮基因的起源。
DOI：
10.1016/s0378-1119(97)00166-2
复制
发表时间：
1997
期刊：
影响因子：
3.5
通讯作者：
Tseng,H
中科院分区：
文献类型：
--
作者：
Tseng,H
四种哺乳动物外皮蛋白基因的共有序列的大部分包含四对互补的寡核苷酸。每对寡核苷酸中的一个富含嘌呤，另一个富含嘧啶。许多对的完美互补性显然是由每个配对寡核苷酸中来自其各自共有序列的一致的单个核苷酸取代引起的。这表明该对中的一个成员通过模板依赖性复制机制来自同一对中的另一个成员。这种复制机制不同于通过在同一条DNA链上产生短互补序列来产生串联重复序列的复制机制。
A large portion of the consensus sequence of four mammalian involucrin genes comprises four pairs of complementary oligonucleotides. One of the oligonucleotides in each pair is rich in purines and the other in pyrimidines. The perfect complementarity of a number of pairs apparently resulted from a concerted single nucleotide substitution in each pairing oligonucleotide from their respective consensus. This suggests that one member of the pair was derived from the other member of the same pair by a template-dependent replication mechanism. Such a replication mechanism differs from the one that creates tandem repeats by producing short complementary sequence on the same strand of DNA.