Virus-induced immune dysregulation as a triggering factor for the development of drug rashes and autoimmune diseases: with emphasis on EB virus, human herpesvirus 6 and hepatitis C virus
Virus-induced immune dysregulation as a triggering factor for the development of drug rashes and autoimmune diseases: with emphasis on EB virus, human herpesvirus 6 and hepatitis C virus
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DOI：
10.1016/s0923-1811(99)00083-3
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发表时间：
2000-04-01
影响因子：
4.6
通讯作者：
Shiohara, T
中科院分区：
文献类型：
--
作者：
Mizukawa, Y;Shiohara, T
关于病毒在药物皮疹和自身免疫性疾病发展中的可能作用，有大量的经验和理论医学文献：在这些条件下，病毒与免疫系统的相互作用将成为疾病发病机制的加速因素。最近的报道提供了证据表明，针对EB（EB）病毒和人类疱疹病毒6（HHV-6）感染的免疫应答。其是疱疹病毒组的亲淋巴细胞成员，不仅有助于病毒的直接清除，而且有助于形成引发或加速药疹的有利环境。尽管对它们有强烈的免疫应答，但可以在宿主的一生中持续存在的病毒，如EB病毒和丙型肝炎病毒（HCV），也与自身免疫性疾病的发病机制有关。据报道，HCV与多种皮肤病有关，通常。组织学上显示苔藓样组织反应。虽然汗孔角化症，表现出苔藓样组织病理学特征一直被认为是与免疫抑制，我们发现，HCV可以作为汗孔角化症的发展在免疫抑制状态的触发器。因此，本综述的主要目的是描述最近的工作，药物皮疹和自身免疫性疾病的病因，特别是病毒感染。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
There are a considerable amount of empirical and theoretic medical literature regarding the possible role of viruses in the development of drug rashes and autoimmune diseases: under these conditions, interactions of viruses with the immune system would serve as an accelerating factor of disease pathogenesis. Recent reports have provided evidence to indicate that immune responses against infections with Epstein-Barr (EB) virus and human herpesvirus 6 (HHV-6). which are lymphotropic members of the herpes virus group, not only aid the direct elimination of the virus but also contribute to a favorable milieu for the initiation or acceleration of drug rashes. Viruses that can persist for the lifetime of the host despite strong immune responses against them, such as EB virus and hepatitis C virus (HCV), would be also relevant to the pathogenesis of autoimmune diseases. HCV has been reportedly associated with a wide variety of dermatoses that, in common. show histologically the lichenoid tissue reaction. Although porokeratosis that manifests lichenoid histopathological features had long been regarded as being associated with immunosuppression, we found that HCV could act as trigger for the development of porokeratosis during states of immunosuppression. Thus, the main purpose of this review is to describe recent work on the etiology of drug rashes and autoimmune disease with special reference to viral infections. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.