Hepatoprotective Effects of Morinda citrifolia Leaf Extract on Ovariectomized Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Histological and Ultrastructural Level
Hepatoprotective Effects of Morinda citrifolia Leaf Extract on Ovariectomized Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Histological and Ultrastructural Level
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DOI：
10.1155/2019/9714302
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发表时间：
2019-11-07
影响因子：
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通讯作者：
Othman, Faizah
中科院分区：
文献类型：
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作者：
Chong, C. L. G.;Hussan, Farida;Othman, Faizah
此前有报道称，海巴戟天（茜草科）或诺丽果的叶子具有广泛的治疗作用，而其果实却很少被描述为具有药用价值。具有讽刺意味的是，人们对这种水果进行了广泛的研究和审查，但人们对叶子作为药用食品的治疗活性知之甚少。本研究的目的是探讨巴戟天 (MC) 乙醇叶提取物对热氧化棕榈油 (TPO) 饮食喂养的绝经后大鼠肝脏结构和功能的治疗作用。 38只雌性Sprague Dawley大鼠分为5组:假手术组(Sham)、去卵巢组(OVX)、去卵巢后给予辛伐他汀10 mg/kg(OVX+ST)、去卵巢后补充低剂量MC 500 mg/kg(OVX+MCLD)、去卵巢后补充高剂量MC 1000 mg/kg。 (OVX+MCHD)。所有去卵巢组均饲喂TPO饮食，而Sham组饲喂正常饮食。绝经后大鼠食用 TPO 饮食会导致肥胖，显着升高（P
Morinda citrifolia (Rubiaceae) or Noni was previously reported to have leaf with broad therapeutic property whereas the fruit was rarely described as medicinal. Ironically, extensive research and review has been done on the fruit and little was known about the therapeutic activity of the leaf as a medicinal food. The aim of this study was to investigate the therapeutic effects of Morinda citrifolia (MC) ethanolic leaf extract on the hepatic structure and function in postmenopausal rats fed with thermoxidized palm oil (TPO) diet. Thirty eight female Sprague Dawley rats were divided into five groups: sham (Sham), ovariectomized (OVX), ovariectomized and treated with simvastatin 10 mg/kg (OVX+ST), ovariectomized and supplemented with low dose MC 500 mg/kg (OVX+MCLD), and ovariectomized and supplemented with high dose MC 1000 mg/kg (OVX+MCHD). All the ovariectomized groups were fed with TPO diet whereas the Sham group was fed with normal diet. Consumption of TPO diet in postmenopausal rats resulted in obesity, significantly elevated (P