Effects of prolactin on the responses of rat aortic and arteriolar smooth-muscle preparations to noradrenaline and angiotensin.
Effects of prolactin on the responses of rat aortic and arteriolar smooth-muscle preparations to noradrenaline and angiotensin.
复制标题
催乳素对大鼠主动脉和小动脉平滑肌制剂对去甲肾上腺素和血管紧张素反应的影响。
DOI：
10.1016/s0140-6736(73)91089-1
复制
发表时间：
1973
期刊：
影响因子：
168.9
通讯作者：
D. Horrobin
中科院分区：
文献类型：
--
作者：
M. Manku;B. Nassar;D. Horrobin
研究了生理和病理生理浓度的催乳素对血管平滑肌对去甲肾上腺素和血管紧张素反应的影响。50纳克。每ml催乳素引起大鼠主动脉条对去甲肾上腺素反应的持续增强;在初始增强浓度为500和5000 ng后。每ml压抑了回应。用大鼠肠系膜血管床制备获得了类似的结果。催乳素浓度为100 ng。每ml似乎是反应模式改变的点。催乳素对肠系膜血管床对血管紧张素的反应有类似的作用。由于刺激，如手术，运动，情绪压力，怀孕，利血平和甲基多巴治疗可能会增加人体血浆催乳素水平到30-500纳克。每毫升，这些结果可能在两性中具有广泛的临床意义。
The effects of physiological and pathophysiological concentrations of prolactin on the responses of vascular smooth muscle to noradrenaline and to angiotensin were studied. 50 ng. per ml. prolactin caused a sustained potentiation of the responses of rat aortic strips to noradrenaline; after an initial potentiation concentrations of 500 and 5000 ng. per ml. depressed the responses. Similar results were obtained with a rat mesenteric vascular-bed preparation. A prolactin concentration of 100 ng. per ml. seemed to be the point at which the response pattern changed. Prolactin had similar effects on the responses of the mesenteric vascular bed to angiotensin. Since stimuli such as surgery, exercise, emotional stress, pregnancy, and treatment with reserpine and methyldopa may increase human plasma-prolactin levels to 30-500 ng. per ml., these results may have wide clinical importance in both sexes.