Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative
Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative
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DOI：
10.1006/excr.1996.0006
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发表时间：
1996-01-10
影响因子：
3.7
通讯作者：
Naus, CCG
中科院分区：
文献类型：
--
作者：
Goldberg, GS;Moreno, AP;Naus, CCG
大黄酸表现出许多药理活性，包括阻断缝隙连接通讯的能力。然而，其作用机制尚不清楚。其他人已经表明，大黄酸显然结合到质膜中的单个蛋白质结合位点。我们目前的证据表明，虽然接触大黄酸衍生物可能不会影响蛋白质的合成或位置，它似乎改变间隙连接斑块中的连接子颗粒包装。(C)出版社：Academic Press，Inc.
Glycyrrhetinic acid exhibits many pharmacological activities, including the ability to block gap junctional communication. However, the mechanism of glycyrrhetinic action is not clear. Others have shown that glycyrrhetinic acid apparently binds to a single proteinatious binding site in the plasma membrane. We present evidence that while exposure to glycyrrhetinic acid derivatives may not affect protein synthesis or location, it does seem to alter connexon particle packing in gap junction plaques. (C) 1996 academic Press, Inc.