SOLUTE AND PENETRANT DIFFUSION IN SWELLABLE POLYMERS .9. THE MECHANISMS OF DRUG RELEASE FROM PH-SENSITIVE SWELLING-CONTROLLED SYSTEMS
SOLUTE AND PENETRANT DIFFUSION IN SWELLABLE POLYMERS .9. THE MECHANISMS OF DRUG RELEASE FROM PH-SENSITIVE SWELLING-CONTROLLED SYSTEMS
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DOI：
10.1016/0168-3659(89)90048-5
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发表时间：
1989-03-01
影响因子：
10.8
通讯作者：
PEPPAS, NA
中科院分区：
文献类型：
--
作者：
BRANNONPEPPAS, L;PEPPAS, NA
共聚物是通过甲基丙烯酸 2-羟乙酯 (HEMA) 与甲基丙烯酸或马来酸酐的本体聚合来制备的。反应用过氧化苯甲酰引发，交联剂为乙二醇二甲基丙烯酸酯，反应温度为40℃至80℃。 C 并增加步长间隔。在不同 pH 值的缓冲水溶液中进行动态膨胀和溶质释放研究。结果表明，在碱性溶液中，控制释放的弛豫控制机制占主导地位。 Deborah 和膨胀界面数用于分析这种扩散释放行为。
Copolymers were prepared by bulk polymerization of 2-hydroxyethyl methacrylate (HEMA) with either methacrylic acid or maleic anhydride. The reaction was initiated with benzoyl peroxide, the crosslinking agent was ethylene glycol dimethacrylate, and the temperature of the reaction varied from 40.degree.C to 80.degree. C and was increased in step intervals. Dynamic swelling and solute release studies were performed in buffered aqueous solutions of various pH values. It was shown that the relaxation-controlled mechanism of controlled release prevailed in alkaline solutions. Deborah and swelling interface numbers were used to analyze this diffusional release behavior.