Do Concentration or Activity of Selenoproteins Change in Acute Stroke Patients? A Systematic Review and Meta-Analyses.
Do Concentration or Activity of Selenoproteins Change in Acute Stroke Patients? A Systematic Review and Meta-Analyses.
复制标题
急性中风患者的硒蛋白浓度或活性会发生变化吗？
DOI：
10.1159/000520856
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Tamburrano S
中科院分区：
文献类型：
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作者：
Tamburrano S
简介：中风的特点是有害的氧化应激。硒蛋白酶是必需的内源性抗氧化剂，对它们在中风后的作用的详细了解可以定义新的治疗方法。这篇系统性综述旨在阐明中风急性期血液硒蛋白浓度和活性的变化。方法：我们检索了PubMed、EMBASE和Medline数据库，以比较急性中风患者或中风患者与非中风对照组的一系列血液硒蛋白浓度或活性。结果：941例中风患者和708例非中风对照组的18项研究和数据纳入本综述。谷胱甘肽过氧化物酶(GPX)是唯一被鉴定的硒蛋白，其活性也是最常被检测到的。12项研究和6 93例患者的研究结果表明，与非卒中对照组相比，急性缺血性卒中患者溶血液中GPx活性升高(标化均数差：0.2 7，95%CI：0.0 7~0.47)，而血浆(标化均数差：−1.08U/L，95%CI：−1.94~−0.2 2)和血清(标化均数差值：−0.5 4，95%CI：−0.91~−0.17)活性降低。在10 6例急性出血性卒中患者的4项研究中，与非出血性卒中对照组相比，溶血液中GPx活性降低(MD：−0.40，95%CI：−0.6 8至−0.13)，而血浆(MD：−0.10U/L，95%CI：−0.81~0.61)和血清(MD：−5.0 0U/mL，95%CI：−36.17~2 6.17)保持不变。结论：我们的研究结果表明急性缺血性卒中患者血液中的GPx活性降低，缺乏关于GPx在出血性卒中患者中的作用的证据，也没有足够的证据证明其他硒蛋白的存在。
Introduction:Stroke is characterized by deleterious oxidative stress. Selenoprotein enzymes are essential endogenous antioxidants, and detailed insight into their role after stroke could define new therapeutic treatments. This systematic review aimed to elucidate how blood selenoprotein concentration and activity change in the acute phase of stroke.Methods:We searched PubMed, EMBASE, and Medline databases for studies measuring serial blood selenoprotein concentration or activity in acute stroke patients or in stroke patients compared to non-stroke controls. Meta-analyses of studies stratified by the type of stroke, blood compartment, and type of selenoprotein measurement were conducted.Results:Eighteen studies and data from 941 stroke patients and 708 non-stroke controls were included in this review. Glutathione peroxidase (GPx) was the only identified selenoprotein, and its activity was most frequently measured. Results from 12 studies and 693 patients showed that compared to non-stroke controls in acute ischaemic stroke patients, the GPx activity increased in haemolysate (standardized mean difference [SMD]: 0.27, 95% CI: 0.07–0.47) but decreased in plasma (mean difference [MD]: −1.08 U/L, 95% CI: −1.94 to −0.22) and serum (SMD: −0.54, 95% CI: −0.91 to −0.17). From 4 identified studies in 106 acute haemorrhagic stroke patients, the GPx activity decreased in haemolysate (SMD: −0.40, 95% CI: −0.68 to −0.13) and remained unchanged in plasma (MD: −0.10 U/L, 95% CI: −0.81 to 0.61) and serum (MD: −5.00 U/mL, 95% CI: −36.17 to 26.17) compared to non-stroke controls. Results from studies assessing the GPx activity in the haemolysate compartment were inconsistent and characterized by high heterogeneity.Conclusions:Our results suggest a reduction of the blood GPx activity in acute ischaemic stroke patients, a lack of evidence regarding a role for GPx in haemorrhagic stroke patients, and insufficient evidence for other selenoproteins.