Altered Functional Connectivity of Fusiform Gyrus in Subjects with Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study.
Altered Functional Connectivity of Fusiform Gyrus in Subjects with Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study.
复制标题
遗忘性轻度认知障碍受试者梭状回功能连接的改变：一项静息态功能磁共振成像研究
DOI：
10.3389/fnhum.2015.00471
复制
发表时间：
2015
影响因子：
2.9
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
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作者：
Cai S;Chong T;Zhang Y;Li J;von Deneen KM;Ren J;Dong M;Huang L;Alzheimer’s Disease Neuroimaging Initiative
视觉认知，如人脸识别，要求网络中分布的大脑区域之间高度的功能集成。有报道称，梭形回(FG)是参与面部认知的重要脑区，FG与其他区域的连接改变可能导致视觉认知，特别是人脸识别的缺陷。然而，在遗忘性轻度认知障碍(Amci)受试者的静息状态下，FG和其他脑区之间的功能连接是否发生变化仍不清楚。在这里，我们使用静息状态功能磁共振成像(FMRI)来检测左/右FG功能连接性的变化，比较年龄匹配的对照组受试者。来自阿尔茨海默病神经成像计划的48名aMCI和38名对照受试者被分析。我们集中研究了FG和所有其他脑区的低频fMRI时间进程之间的相关性。与对照组相比，aMCI组在左侧楔前、左侧舌回、右侧丘脑、边缘上回、左侧辅助运动区、左侧颞下回、左侧副海马区等与左侧/右侧FG连接性增强或减弱的脑区有差异。更重要的是，在aMCI患者中，左、右FG与左侧枕中回(MOG)和右侧扣带前回(ACC)的功能联系均增强。这并不是巧合，可能意味着MOG和ACC在视觉认知，特别是人脸识别中也发挥着关键作用。这些发现在很大程度上支持了我们的假设，并为理解MCI的重要亚型提供了新的见解。
Visual cognition such as face recognition requests a high degree of functional integration between distributed brain areas of a network. It has been reported that the fusiform gyrus (FG) is an important brain area involved in facial cognition; altered connectivity of FG to some other regions may lead to a deficit in visual cognition especially face recognition. However, whether functional connectivity between the FG and other brain areas changes remains unclear in the resting state in amnestic mild cognitive impairment (aMCI) subjects. Here, we employed a resting-state functional MRI (fMRI) to examine alterations in functional connectivity of left/right FG comparing aMCI patients with age-matched control subjects. Forty-eight aMCI and 38 control subjects from the Alzheimer’s disease Neuroimaging Initiative were analyzed. We concentrated on the correlation between low frequency fMRI time courses in the FG and those in all other brain regions. Relative to the control group, we found some discrepant regions in the aMCI group which presented increased or decreased connectivity with the left/right FG including the left precuneus, left lingual gyrus, right thalamus, supramarginal gyrus, left supplementary motor area, left inferior temporal gyrus, and left parahippocampus. More importantly, we also obtained that both left and right FG have increased functional connections with the left middle occipital gyrus (MOG) and right anterior cingulate gyrus (ACC) in aMCI patients. That was not a coincidence and might imply that the MOG and ACC also play a critical role in visual cognition, especially face recognition. These findings in a large part supported our hypothesis and provided a new insight in understanding the important subtype of MCI.