Alterations in Lactoferrin in Salivary Gland Disease
Alterations in Lactoferrin in Salivary Gland Disease
复制标题
唾液腺疾病中乳铁蛋白的变化
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
H. Baurmash
中科院分区：
文献类型：
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作者：
Lawrence Tabak;I. Mandel;Daniel Karlan;H. Baurmash
在慢性复发性腮腺炎的活跃期，腮腺中乳铁蛋白（Lf）的浓度显著升高，乳铁蛋白是一种具有抗菌特性的铁结合糖蛋白。Lf浓度在恢复期下降，但仍高于正常水平。乳腺炎和胰腺炎中Lf的变化与最近的发现相似。6名患有Sjögren疾病的受试者中有5名也注意到Lf升高，但在结节病、糖尿病或无唾液学改变的“口干”受试者中没有。Lf的来源尚未确定；它可能部分来自于破坏多形核白细胞，部分来自于唾液腺中合成Lf的上皮细胞。炎症刺激Lf合成提示外分泌腺的基本保护机制，值得充分探讨。
During the active phase of chronic recurrent parotitis there is a marked elevation in the parotid concentration of lactoferrin (Lf), an iron-binding glycoprotein with antibacterial properties. The Lf concentration decreases during the recovery period, but still remains above normal levels. The changes of Lf in parotitis parallel recent findings in mastitis and pancreatitis. Elevations in Lf were also noted in five of six subjects with Sjögren's disease, but not in subjects with sarcoidosis, diabetes or "dry mouth" without sialographic changes. The source of the Lf has not been determined; it could arise in part from disrupting polymorphonuclear leucocytes and in part from epithelial cells that synthesize Lf in the salivary glands. Inflammatory stimulation of Lf synthesis would suggest a basic protective mechanism in exocrine glands and should be fully explored.