Cytotoxic new caged-polyprenylated xanthonoids from Garcinia oligantha
Cytotoxic new caged-polyprenylated xanthonoids from Garcinia oligantha
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DOI：
10.1016/j.fitote.2021.105092
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发表时间：
2021-12-01
期刊：
影响因子：
3.4
通讯作者：
Ren, Dongmei
中科院分区：
文献类型：
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作者：
Liu, Qingying;Zheng, Hao;Ren, Dongmei
笼状聚异戊二烯化黄嘌呤是一类罕见的天然产物。该类化合物主要从藤黄属植物中分离得到。对少花山竹（Garcinia oligantha）的叶和枝进行植物化学研究，分离到4个新的笼状聚异戊二烯基黄酮化合物，即少花山竹酮C-F（1-4）和2个新的简单黄酮化合物，即少花山竹酮D和少花山竹酮E（5-6）。还分离了八种已知的其他聚异戊二烯化的氧杂蒽酮（7-14），包括五种笼状聚异戊二烯化的氧杂蒽酮（7-11）。通过大量的光谱数据分析，确定了它们的结构。除5、6和14外，所有分离的化合物对人肺癌A549细胞显示出细胞活力降低作用。化合物1-3被证明是潜在的细胞凋亡诱导剂。
Caged-polyprenylated xanthonoids represent a rare class of natural products. This type of compounds is mainly isolated from Genus Garcinia. Phytochemical studies on the leaves and twigs of Garcinia oligantha led to the isolation of four new caged-polyprenylated xanthonoids, oliganthone C-F (1-4), and two new simple xanthones (5-6), oliganthaxanthone D and oliganthaxanthone E. Eight known other polyprenylated xanthones (7-14) including five caged-polyprenylated xanthonoids (7-11) were also isolated. Their structures were elucidated based on the analyses of extensive spectroscopic data. All the isolated compounds except for 5, 6 and 14 showed cell viability reducing effect against human lung cancer A549 cells. Compounds 1-3 were proved to be potential apoptosis inducing agents.