Ran at kinetochores
Ran at kinetochores
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DOI：
10.1042/bst0340711
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发表时间：
2006-11-01
影响因子：
3.9
通讯作者：
Dasso, M.
中科院分区：
文献类型：
--
作者：
Dasso, M.
Ran GTPase控制着许多细胞功能，包括核胞质运输、纺锤体组装、核组装和细胞周期进程。大量证据表明，有丝分裂染色质附近可扩散的Ran-GTP有助于核转运受体释放关键因子，从而促进有丝分裂纺锤体相对于染色体的组织。除了可溶性Ran- gtp的作用外，Ran在有丝分裂着丝点中还有两个重要但鲜为人知的作用。也就是说，它对于纺锤体组装检查点的调节和将着丝点连接到纺锤体极点的微管纤维的组装是必不可少的。在这里，我将简要地总结这些与着丝酶相关的功能的证据，并提到一些有待解决的问题。
The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic spindles with respect to chromosomes. In addition to this role of soluble Ran-GTP, Ran has two important but less understood roles at mitotic kinetochores. Namely, it is essential for regulation of the spindle assembly checkpoint and for assembly of microtubule fibres that attach kinetochores to spindle poles. Here, I will briefly summarize evidence for these kinetochore-associated functions and mention some of the issues that remain to be addressed regarding them.