Lack of serological evidence for an association between simian virus 40 and lymphoma.
Lack of serological evidence for an association between simian virus 40 and lymphoma.
复制标题
缺乏猴病毒 40 与淋巴瘤之间关联的血清学证据。
DOI：
10.1002/ijc.10993
复制
发表时间：
2003
影响因子：
6.4
通讯作者：
Viscidi,RaphaelP
中科院分区：
文献类型：
--
作者：
deSanjose,Silvia;Shah,KeertiV;Domingo-Domenech,Eva;Engels,EricA;FernandezdeSevilla,Alberto;Alvaro,Tomas;Garcia-Villanueva,Mercedes;Romagosa,Vicens;Gonzalez-Barca,Eva;Viscidi,RaphaelP
Recent studies have implicated simian virus 40 (SV40) in non‐Hodgkin's lymphomas based on detection of SV40 DNA sequences. We employed a virus‐like‐particle (VLP)‐based enzyme immunoassay for antibodies to SV40 to test sera from 520 lymphoma cases and 587 controls in Spain. The SV40 seroprevalence was 9.5% in controls and 5.9% in cases. Antibody levels of the positive sera were low. There was no association of SV40 seropositivity with any subtype of lymphoma. VLPs of the human BK virus substantially inhibited the SV40 reactivity of human sera. There was no serological evidence of widespread SV40 infection and no association of SV40 seropositivity with human lymphomas in Spain. © 2003 Wiley‐Liss, Inc.
