Neutrophil function in the dog: shape change and response to a synthetic tripeptide.
Neutrophil function in the dog: shape change and response to a synthetic tripeptide.
复制标题
狗的中性粒细胞功能：形状变化和对合成三肽的反应。
DOI：
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发表时间：
1985
影响因子：
1
通讯作者：
C. W. Smith
中科院分区：
文献类型：
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作者：
J. Stickle;D. Kwan;C. W. Smith
暴露于已知趋化因子的孤立犬中性粒细胞在悬浮液中呈现双极构型。这种反应在2分钟内开始，逐渐恢复到球形。回球率与兴奋剂剂量呈正相关。暴露于N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（fMLP）的犬中性粒细胞不适应双极构象，也不结合放射性标记的fMLP。这些发现与其他物种（猪和牛）一致，这些物种也对fMLP没有反应。
Isolated dog neutrophils exposed to known chemotactic factors assumed a bipolar configuration in suspension. This response was initiated within 2 minutes with a gradual return to spherical shape. The rate of return to sphere was positively correlated with the dose of stimulant. Dog neutrophils exposed to N-formylmethionyl-leucyl-phenylalanine (fMLP) did not adapt to bipolar conformation and did not bind radiolabeled fMLP. These findings are consistent with other species (pig and cow) that also did not respond to fMLP.