A New View into the Regulation of Purine Metabolism: The Purinosome.
A New View into the Regulation of Purine Metabolism: The Purinosome.
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对嘌呤代谢调节的新观点：嘌呤体。
DOI：
10.1016/j.tibs.2016.09.009
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发表时间：
2017-02
影响因子：
13.8
通讯作者：
Benkovic SJ
中科院分区：
文献类型：
--
作者：
Pedley AM;Benkovic SJ
嘌呤代谢物除了作为DNA和RNA的组成部分外，还为细胞提供必要的能量和辅助因子，以促进细胞的存活和增殖。对嘌呤代谢如何促进癌症进展的新兴趣揭示了细胞如何调节嘌呤需求的新视角。在高嘌呤需求的细胞条件下，新的嘌呤生物合成酶聚集在线粒体和微管附近，形成动态的多酶复合物，称为嘌呤体。这篇综述强调了嘌呤酶体作为细胞中酶代谢组织的一种新水平，它对嘌呤代谢调节的影响，以及嘌呤代谢被靶向治疗癌症的程度。
Other than serving as building blocks for DNA and RNA, purines metabolites provide a cell with the necessary energy and cofactors to promote cell survival and proliferation. A renewed interest in how purine metabolism may fuel cancer progression has uncovered a new perspective into how a cell regulates purine need. Under cellular conditions of high purine demand, the de novo purine biosynthetic enzymes cluster near mitochondria and microtubules to form dynamic multi-enzyme complexes referred to as purinosomes. This review highlights the purinosome as a novel level of metabolic organization of enzymes in cells, its consequences for regulation of purine metabolism, and the extent that purine metabolism is being targeted for the treatment of cancers.