EFFECT OF WHISKEY ON ATRIAL VULNERABILITY AND HOLIDAY HEART
EFFECT OF WHISKEY ON ATRIAL VULNERABILITY AND HOLIDAY HEART
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DOI：
10.1016/s0735-1097(83)80195-8
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发表时间：
1983-01-01
影响因子：
24
通讯作者：
LUCK, JC
中科院分区：
文献类型：
--
作者：
ENGEL, TR;LUCK, JC
对 11 名没有心肌病或明显心力衰竭的酗酒者进行了心房颤动和扑动的脆弱性检查。心房额外刺激以快速起搏（驱动周期长度 500 毫秒）进行，以促进心房脆弱性的诱导，这在 4 名酗酒者中观察到。其余7人在饮用60至120毫升86度威士忌后30分钟重新进行测试（血液乙醇浓度为49至101毫克/100毫升，但肺毛细血管楔压均保持正常），其中3人诱发心房颤动或心房扑动。三名不喝酒的人，有窦性心动过缓的症状，但没有心力衰竭的症状，被发现不易患心房颤动或心房扑动，但三人中的两人在喝了威士忌后诱发了心房颤动。威士忌不会改变心房功能不应期（平均值 .+-. 平均值的标准误差 297 .+-. 14 至 290 .+-. 12 毫秒）或扩大 3 个不同右心房部位之间的离散度（57 .+-. 13 至 47 .+-. 12 毫秒）。威士忌显然会增加没有心力衰竭或心肌病的患者患房颤和心房扑动的可能性，证实了假日心脏综合症。
Vulnerability of atrial fibrillation and flutter was examined in 11 alcohol abusers who did not have cardiomyopathy or manifest heart failure. Atrial extrastimulation was done with rapid pacing (drive cycle length 500 ms) to facilitate induction of atrial vulnerability, seen in 4 alcohol abusers. The remaining 7 were retested 30 min after drinking 60 to 120 ml of 86 proof whiskey (ethanol blood levels were 49 to 101 mg/100 ml but pulmonary capillary wedge pressure remained normal in all) and atrial fibrillation or flutter was induced in 3 of the drinkers. Three nondrinkers, symptomatic with sinus bradycardia but not in heart failure, were found not to be vulnerable to atrial fibrillation or flutter, but flutter was induced in 2 of the 3 after drinking whiskey. Whiskey did not alter atrial functional refractory periods (mean .+-. standard error of the mean 297 .+-. 14 to 290 .+-. 12 ms) or widen the dispersion among 3 disparate right atrial sites (57 .+-. 13 to 47 .+-. 12 ms). Whiskey evidently enhances vulnerability to atrial fibrillation and flutter in patients without heart failure or cardiomyopathy, substantiating the holiday heart syndrome.