Recognition properties of receptors based on dimesitylmethane-derived core: di- vs. monosaccharide preference.
Recognition properties of receptors based on dimesitylmethane-derived core: di- vs. monosaccharide preference.
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基于二甲甲烷衍生核心的受体的识别特性：二糖与单糖偏好。
DOI：
10.1039/b901173k
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发表时间：
2009
影响因子：
3.2
通讯作者：
A. Buthe
中科院分区：
文献类型：
--
作者：
M. Mazik;A. Buthe
二均三甲苯衍生的受体12和13，纳入四个杂环识别基团能够作为氢键位点，被设计为识别二糖。通过1H NMR和荧光光谱滴定已经表明，化合物12和13显示出对α-和β-麦芽糖苷的高结合亲和力，以及在有机介质中对单糖的强烈偏好。如实验数据和分子模拟计算所示，氢键和糖CH与受体苯环的相互作用有助于受体-糖复合物的稳定。
Dimesitylmethane-derived receptors 12 and 13, incorporating four heterocyclic recognition groups capable of serving as hydrogen bonding sites, were designed to recognize disaccharides. It has been shown by 1H NMR and fluorescence spectroscopic titrations that compounds 12 and 13 display high binding affinities toward alpha- and beta-maltoside, as well as strong di- vs monosaccharide preference in organic media. Both hydrogen-bonding and interactions of the sugar CH's with the phenyl rings of the receptor contribute to the stabilisation of the receptor-sugar complexes, as indicated by experimental data and molecular modeling calculations.
影响因子：
4.9
作者：
Kiehna, Sarah E.;Laughrey, Zachary R.;Waters, Marcey L.
通讯作者：
Waters, Marcey L.