Ovarian cyst formation in patients using tamoxifen for breast cancer
Ovarian cyst formation in patients using tamoxifen for breast cancer
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DOI：
10.1093/jjco/hyi165
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发表时间：
2005-10-01
影响因子：
2.4
通讯作者：
Bilir, G
中科院分区：
文献类型：
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作者：
Metindir, J;Aslan, S;Bilir, G
目的：通过对2002年1月至2004年12月在安卡拉肿瘤医院门诊接受三苯氧胺治疗的乳腺癌患者进行回顾性分析，探讨影响患者卵巢囊肿形成的相关因素。记录他莫昔芬的剂量和疗程、治疗后月经功能、辅助治疗、超声检查和激素(卵泡刺激素和血清雌二醇，E-2)资料、妇科手术细节和组织病理学。结果：150例接受他莫昔芬治疗的患者中，29例(19.3%)发生卵巢囊肿。在57名绝经前妇女中有28人(49.1%)和93名绝经后妇女中有1人(1.1%)发现了包囊。卵巢囊肿组的血清E-2水平高于非囊肿组(24pg/ml比345pg/ml；P<；0.001)。卵巢囊肿组与非囊肿组相比，闭经持续时间为1年(P<；0.001)。辅助标准化疗与卵巢囊肿的发生无明显关系。多因素分析显示，卵巢囊肿的发生与高E-2水平有关(P<；0.05)。结论：在三苯氧胺期间仍有月经周期的患者发生卵巢囊肿的风险较高(58.33%)。我们已经描述了绝经前患者使用高E-2水平的他莫昔芬与卵巢囊肿大之间的关系。
Objective: The purpose of this study was to evaluate patient-related parameters that determine ovarian cyst formation in women using tamoxifen for breast cancer.Methods: A retrospective review of tamoxifen-treated women with breast cancer who were followed up in the outpatient clinic at Ankara Oncology Hospital between January 2002 and December 2004 was performed. Tamoxifen doses and duration, post-treatment menstrual function, adjuvant therapy, ultrasonographic and hormonal [follicle-stimulating hormone and serum estradiol (E-2)] data, details of gynecologic surgical procedure and histopathology were recorded.Results: Twenty-nine of 150 tamoxifen-treated patients (19.3%) had ovarian cysts. Cysts were detected in 28 of 57 pre-menopausal women (49.1%) and 1 of 93 post-menopausal women (1.1%). Patients with ovarian cysts had higher serum E-2 levels compared with patients without cysts (24 versus 345 pg/ml; P < 0.001). Patients with ovarian cysts had < 1 year amenorrhoea duration (P < 0.001) compared with the patients without cysts. Adjuvant standard chemotherapy did not have relationship between the development of ovarian cysts. Multivariant analysis showed that cyst development is related to high E-2 levels (P < 0.05).Conclusions: Patients still having a menstrual cycle during tamoxifen had high risk (58.33%) of developing ovarian cysts. We have described an association between pre-menopausal patients using tamoxifen with high E-2 level and ovarian cyst enlargement.