Effects of Cutaneous Gastric Electrical Stimulation on Gastric Emptying and Postprandial Satiety and Fullness in Lean and Obese Subjects
Effects of Cutaneous Gastric Electrical Stimulation on Gastric Emptying and Postprandial Satiety and Fullness in Lean and Obese Subjects
复制标题
皮肤胃电刺激对瘦和肥胖受试者胃排空和餐后饱腹感的影响
DOI：
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发表时间：
2010
影响因子：
2.9
通讯作者：
Jiande D. Z. Chen
中科院分区：
文献类型：
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作者：
Jing Wang;Jun Song;X. Hou;Jinsong Liu;Jiande D. Z. Chen
目的探讨快速胃电刺激(CGES)治疗肥胖症的可能性。背景：埋藏式胃电刺激器已被提出用于治疗肥胖，最近有报道称，胃过速频率的胃电刺激抑制了胃运动。研究方法10名瘦身健康志愿者和10名肥胖健康志愿者被随机分为3组：无CGES组、生理频率CGES组(3 周期/分钟)和胃速频率CGES组(12 周期/分钟)。使用正弦波进行电刺激。该方案包括以下顺序：20分钟基线，30分钟CGES，30分钟不记录CGES，30分钟CGES，摄入500 大卡液体餐，以及30分钟CGES。无CGES时，用体表胃电描记记录胃慢波。超声检查胃排空功能。记录患者的消化不良症状。结果(1)两组受试者胃排空的半衰期分别为(75.0±16.5) m in比(41.0±8.7) m in(P<0.0 1)和肥胖组(6 4.1±13.3 m in对32.7±5.0 m in，P<0.0 1)。(2)无论是瘦肉型(3.2±1.47)分还是肥胖型(3.9±1.89)分，两组餐后消化不良症状评分(主要是饱腹感和饱腹感)均显著高于生理频率组(3.2±1.47比1.7±0.94，P<；0.01)。结论胃速快的CGES可增加餐后饱足感，延缓胃排空。它对肥胖症的治疗潜力还需要研究。
Goals The aim of this study was to investigate the therapeutic potential of cutaneous gastric electrical stimulation (CGES) at a tachygastrial frequency for obesity. Background Implantable gastric electrical stimulator has been proposed for the treatment of obesity and it has recently been reported that the gastric electrical stimulation at a tachygastrial frequency inhibits gastric motility. Study Methods Ten lean and 10 obese healthy volunteers were studied in 3 randomized sessions: no CGES, CGES at the physiologic frequency (3 cycles/min), and CGES at tachygastrial frequency (12 cycles/min). Electrical stimulation was performed using sinusoidal waves. The protocol included the following sequence: 20-minute baseline, 30-minute CGES, 30-minute recording without CGES, 30-minute CGES, ingestion of a 500 kcal liquid meal, and 30-minute CGES. Gastric slow waves were recorded using cutaneous electrogastrography during the periods without CGES. Gastric emptying was assessed by ultrasound. Dyspeptic symptoms were recorded. Results (1) The half-time of gastric emptying was longer with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean subjects (75.0±16.5 min vs. 41.0±8.7 min, P<0.01) and obese subjects (64.1±13.3 min vs. 32.7±5.0 min, P<0.01). (2) Postprandial dyspeptic symptom score (mainly satiety and fullness) was significantly higher with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean (3.2±1.47 vs. 1.7±0.94, P<0.01) and obese (3.9±1.89 vs. 1.8±1.15, P<0.01) subjects. Conclusions CGES at a tachygastrial frequency enhances postprandial fullness and satiety, and delays gastric emptying. Its therapeutic potential for obesity needs to be studied.
影响因子：
120.7
作者：
Allison, DB;Fontaine, KR;VanItallie, TB
通讯作者：
VanItallie, TB
DOI：
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发表时间：
1994
期刊：
The American journal of gastroenterology
影响因子：
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作者：
Chen,JD;Richards,RD;McCallum,RW
通讯作者：
McCallum,RW
DOI：
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发表时间：
1993
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Chen,JD;McCallum,RW
通讯作者：
McCallum,RW