Identification of autoantibodies associated with myelin damage in multiple sclerosis
Identification of autoantibodies associated with myelin damage in multiple sclerosis
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DOI：
10.1038/5532
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发表时间：
1999-02-01
期刊：
影响因子：
82.9
通讯作者：
Raine, CS
中科院分区：
文献类型：
--
作者：
Genain, CP;Cannella, B;Raine, CS
多发性硬化病变中髓鞘破坏的分子机制尚未解决。与免疫金标记的髓鞘抗原肽和高分辨率显微镜，技术，可以检测抗原特异性抗体原位，我们已经确定了自身抗体特异性的中枢神经系统髓鞘抗原髓鞘/少突胶质细胞糖蛋白。这些自身抗体特异性地结合在急性多发性硬化症和变应性脑脊髓炎的绒猴模型中的轴突周围的崩解髓鞘上。这些发现代表了直接的证据，针对特定髓鞘蛋白的自身抗体介导中枢神经系统脱髓鞘疾病的靶膜损伤。
The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin antigens and high-resolution microscopy, techniques that can detect antigen-specific antibodies in situ, we have identified autoantibodies specific for the central nervous system myelin antigen myelin/oligodendrocyte glycoprotein. These autoantibodies were specifically bound to disintegrating myelin around axons in lesions of acute multiple sclerosis and the marmoset model of allergic encephalomyelitis. These findings represent direct evidence that autoantibodies against a specific myelin protein mediate target membrane damage in central nervous system demyelinating disease.