In vivo fate of Ag2Te quantum dot and comparison with other NIR-II silver chalcogenide quantum dots
In vivo fate of Ag2Te quantum dot and comparison with other NIR-II silver chalcogenide quantum dots
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Ag2Te 量子点的体内命运以及与其他 NIR-II 银硫族化物量子点的比较
DOI：
10.1007/s11051-020-04992-7
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发表时间：
2020
影响因子：
2.5
通讯作者：
Wang Haifang
中科院分区：
文献类型：
--
作者：
Zhang Jun-Zheng;Tang Huan;Chen Xing-Zhu;Su Qianqian;Xi Wen-Song;Liu Yuan-Yuan;Liu Yuanfang;Cao Aoneng;Wang Haifang
窄带隙Ag2Te量子点（QDs）在生物成像、化学/生物检测和热电材料等领域具有广阔的应用前景，但其生物安全性尚未得到很好的评价。本研究研究了聚乙二醇包被Ag2Te QDs （Ag2Te QDs- peg）单次静脉注射后在小鼠体内的生物分布和毒性。进入小鼠体内后，Ag2Te QDs-PEG在血液中循环时间短（半衰期小于2 h），主要积聚在肝脏和脾脏。Ag2Te QDs-PEG在小鼠体内的稳定性取决于积累器官和时间。Ag2Te QDs-PEG在脾脏中28 d内稳定，7 d后在肝脏中分解。分解的Ag2Te QDs-PEG通过不同的途径从体内排出，因为Ag只在粪便中检测到，而Te只在尿液中发现。同时，Ag2Te QDs-PEG对28 d的体重、器官指数、生化参数、器官中必需金属Cu和Zn水平以及器官病理检查均无明显不良影响。此外，通过比较Ag2Te量子点和其他两种银量子点（Ag2S和Ag2Se）在体内的分布，证明了阴离子对银量子点命运的重要影响。研究结果表明，Ag2Te量子点在小鼠体内具有良好的生物相容性，为其今后的安全应用提供了保障。
Narrow bandgap Ag2Te quantum dot (QDs) hold great promise in the fields of bioimaging, chemo-/bio-detection, and thermoelectric materials, but their biosafety has not been well estimated yet. In this study, we studied the biodistribution and toxicity of polyethylene glycol–coated Ag2Te QDs (Ag2Te QDs-PEG) in mice after a single intravenous injection. After entering the mice, Ag2Te QDs-PEG displayed a short circulation time in the blood (half-life was less than 2 h), and mainly accumulated in the liver and spleen. The stability of Ag2Te QDs-PEG in the mice depended on accumulation organ and time. Ag2Te QDs-PEG were stable in the spleen within 28 days but decomposed in the liver after 7 days. The decomposed Ag2Te QDs-PEG were eliminated from the body via different routes, as Ag was detected only in feces while Te was found only in urine. Meanwhile, Ag2Te QDs-PEG did not show obvious adverse effects on the body weights, organ indices, biochemical parameters, the levels of essential metal Cu and Zn in organs, and organ pathological investigations during 28 days. In addition, the important effects of anion to the fates of silver chalcogenide QDs in vivo was demonstrated by comparing the distributions of the Ag2Te QDs and other two silver chalcogenide QDs (Ag2S and Ag2Se). Our findings indicate Ag2Te QDs have good biocompatibility in mice, which is a guarantee for their safe applications in the future.