TUMOR-NECROSIS-FACTOR-ALPHA IN STOOL AS A MARKER OF INTESTINAL INFLAMMATION
TUMOR-NECROSIS-FACTOR-ALPHA IN STOOL AS A MARKER OF INTESTINAL INFLAMMATION
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DOI：
10.1016/0140-6736(92)90999-j
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发表时间：
1992-01-11
期刊：
影响因子：
168.9
通讯作者：
MACDONALD, TT
中科院分区：
文献类型：
--
作者：
BRAEGGER, CP;NICHOLLS, S;MACDONALD, TT
炎症性肠病患者疾病活动度的测量是困难的。最好的方法是复杂和耗时的，但它可能使用粪便中的肿瘤坏死因子α（TNF-α）浓度作为疾病活动的标志物。我们测量了正常儿童、腹泻婴儿和炎症性肠病儿童在疾病活动期和非活动期的粪便样本中的TNF-α浓度。在10名正常儿童和14名腹泻儿童中，粪便TNF-α浓度的中位数分别为58和45 pg/g粪便。与肠道对照组相比，活动性克罗恩病（n = 13，中位数994 pg/g，p < 0.0002）和活动性溃疡性结肠炎（n = 4，范围276-5982 pg/g，p < 0.003）患儿的粪便TNF-α浓度显著升高。在非活动性疾病的患者中，无论是手术还是类固醇治疗，粪便TNF-α的浓度下降到对照组的水平，粪便TNF-α浓度的测量可能提供一种简单的方法来监测炎症性肠病的疾病活动性。
Measurement of disease activity in patients with inflammatory bowel disease is difficult. The best available methods are complex and time consuming, but it may be possible to use tumour necrosis factor alpha (TNF-alpha) concentration in stool as a marker of disease activity. We measured TNF-alpha concentrations in stool samples from normal children, infants with diarrhoea, and children with inflammatory bowel disease in active and inactive phases of the disease.In 10 normal children and 14 children with diarrhoea, median stool TNF-alpha concentrations were 58 and 45 pg/g stool, respectively. Compared with diarrhoeal controls, stool TNF-alpha concentrations were significantly increased in children with active Crohn's disease (n = 13, median 994 pg/g, p < 0.0002) and active ulcerative colitis (n = 4, range 276-5982 pg/g, p < 0.003). In patients with inactive disease, either as a result of surgery or treatment with steroids, the concentration of stool TNF-alpha fell to those of controls.Measurement of stool TNF-alpha concentations may provide a simple way to monitor disease activity in inflammatory bowel disease.