ULCERATIVE KERATITIS - SURVEY OF 30 YEARS LABORATORY EXPERIENCE
ULCERATIVE KERATITIS - SURVEY OF 30 YEARS LABORATORY EXPERIENCE
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DOI：
10.1001/archopht.1982.01030030079005
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发表时间：
1982-01-01
影响因子：
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通讯作者：
STENSON, S
中科院分区：
文献类型：
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作者：
ASBELL, P;STENSON, S
在30年的时间里，在677例感染性角膜溃疡病例中，有547例在革兰氏染色和培养中鉴定出了致病菌。即使革兰氏染色上没有看到微生物，培养结果也常常是阳性的。葡萄球菌是最常见的分离物；其次是莫拉菌、假单胞菌和肺炎链球菌。只有1%的病例是真菌感染。溃疡的位置、有无脓肿和穿孔对确定病原有一定的帮助。大多数边缘病变是葡萄球菌感染的结果；中枢性病变更可能是革兰氏阴性溃疡。真菌性溃疡是通过实验室检查而不是临床特征来确定的。莫拉菌感染几乎只发生在营养不良的患者中。假单胞菌溃疡常见于大面积烧伤患者或接受呼吸辅助的患者。庆大霉素和新霉素是最有效的治疗方法。
During a 30 yr period, causative organisms were identified on Gram''s stain and culture in 547 of 677 cases of infectious corneal ulcers. Even if no organisms were seen on Gram''s stain, culture results were often positive. Staphylococcus was the most common isolate; Moraxella, Pseudomonas and Streptococcus pneumoniae were the next most frequent pathogens. Only 1% of cases was fungal. Of some help in identifying the causative organism were locations, presence or absence of hypopyon and perforation of the ulcer. Most marginal lesions were a result of staphylococcal infection; central lesions were more likely to be gram-negative ulcers. Fungal ulcers were identified by laboratory workup and not by clinical characteristics. Moraxella infection was observed almost exclusively in malnourished patients. Pseudomonas ulcers were often seen in patients with large body burns or patients receiving respiratory assistance. Gentamicin and neomycin were the most effective treatments.