Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults
Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults
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DOI：
10.1093/eurheartj/ehq068
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发表时间：
2010-07-01
影响因子：
39.3
通讯作者：
Boeing, Heiner
中科院分区：
文献类型：
--
作者：
Buijsse, Brian;Weikert, Cornelia;Boeing, Heiner
目的探讨巧克力摄入量与测量血压(BP)和心血管疾病(CVD)发病率的关系。方法和结果在欧洲癌症和营养前瞻性调查的波茨坦分支机构，19357名参与者(年龄35-65岁)在无心肌梗死(MI)和中风的情况下，在基线(1994-98)的基础上评估了包括巧克力和血压在内的饮食摄入量。经过近8年的平均随访，发现了166例心肌梗塞和136例中风的病例。与巧克力消费量最低的四分位数相比，平均收缩压为1.0毫米汞柱[95%可信区间-1.6至-0.4毫米汞柱]，平均舒张压0.9毫米汞柱(95%可信区间为-1.3至-0.5毫米汞)。心梗和卒中合并结局在顶部和底部四分位数的相对风险为0.61(95%可信区间为0.44-0.87；P线性趋势=0.014)。基线血压解释了12%的低风险(95%可信区间3-36%)。中风的负相关性强于心肌梗死。结论巧克力的摄入似乎降低了心血管疾病风险，部分是通过降低血压。中风患者的反向关联可能比心肌梗死患者更强。还需要进一步的研究，特别是随机试验。
Aims To investigate the association of chocolate consumption with measured blood pressure (BP) and the incidence of cardiovascular disease (CVD).Methods and results Dietary intake, including chocolate, and BP were assessed at baseline (1994-98) in 19 357 participants (aged 35-65 years) free of myocardial infarction (MI) and stroke and not using antihypertensive medication of the Potsdam arm of the European Prospective Investigation into Cancer and Nutrition. Incident cases of MI (n = 166) and stroke (n 136) were identified after a mean follow-up of similar to 8 years. Mean systolic BP was 1.0 mmHg [95% confidence interval (CI) -1.6 to -0.4 mmHg] and mean diastolic BP 0.9 mmHg (95% CI -1.3 to -0.5 mmHg) lower in the top quartile compared with the bottom quartile of chocolate consumption. The relative risk of the combined outcome of MI and stroke for top vs. bottom quartiles was 0.61 (95% CI 0.44-0.87; P linear trend = 0.014). Baseline BP explained 12% of this lower risk (95% CI 3-36%). The inverse association was stronger for stroke than for MI.Conclusion Chocolate consumption appears to lower CVD risk, in part through reducing BP. The inverse association may be stronger for stroke than for MI. Further research is needed, in particular randomized trials.