Optimal influenza vaccine distribution with equity
Optimal influenza vaccine distribution with equity
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DOI：
10.1016/j.ejor.2019.11.025
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发表时间：
2020-06-01
影响因子：
6.4
通讯作者：
Ozaltin, Osman Y.
中科院分区：
文献类型：
--
作者：
Enayati, Shakiba;Ozaltin, Osman Y.
研究了由多个亚群组成的异质群体中流感疫苗的最优分配问题。我们采用了一个房室模型的流感传播，并制定了一个数学计划，以尽量减少疫苗剂量的数量分布，有效地扑灭了新出现的疫情在其早期阶段。我们提出了一个公平约束，以帮助公共卫生当局考虑公平时，作出疫苗分配的决定。我们开发了一个精确的解决方案的方法，产生一个疫苗分配政策的解决方案的质量保证。我们进行敏感性分析的关键流行病参数，以说明所提出的模型的应用。然后，我们分析的可扩展性的解决方案的方法，人口组成的子组的基础上的地理位置和年龄。最后，我们证明了所提出的模型的能力，考虑疫苗覆盖率的不公平性，并讨论了一个无导数的优化方法，作为一种替代的解决方案，可以考虑各种不同的目标函数和约束。我们的研究结果表明，考虑特定群体的传播动力学是至关重要的流感疫苗的最佳分配。(C)2019爱思唯尔B.V.保留所有权利。
This paper is concerned with the optimal influenza vaccine distribution in a heterogeneous population consisting of multiple subgroups. We employ a compartmental model for influenza transmission and formulate a mathematical program to minimize the number of vaccine doses distributed to effectively extinguish an emerging outbreak in its early stages. We propose an equity constraint to help public health authorities consider fairness when making vaccine distribution decisions. We develop an exact solution approach that generates a vaccine distribution policy with a solution quality guarantee. We perform sensitivity analyses on key epidemic parameters in order to illustrate the application of the proposed model. We then analyze the scalability of the solution approach for a population consisting of subgroups based on geographic location and age. We finally demonstrate the proposed model's ability to consider vaccine coverage inequity and discuss a derivative-free optimization approach, as an alternative solution method which can consider various different objective functions and constraints. Our results indicate that consideration of group-specific transmission dynamics is paramount to the optimal distribution of influenza vaccines. (C) 2019 Elsevier B.V. All rights reserved.